不同亚型幼年特发性关节炎患儿免疫功能指标及关节炎抗体比较

doi:10.3969/j.issn.1671-7171.2026.03.024

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Abstract 【Objective】 To explore the differences in immunity and arthritis antibodies in children with different subtypes of juvenile idiopathic arthritis. 【Methods】 A total of 104 children with juvenile idiopathic arthritis admitted to our clinic from October 2019 to October 2024 were selected and divided into three groups according to the type of idiopathic arthritis: systemic type group (n=38), polyarticular type group (n=24), and oligoarticular type group (n=42). Immune function indicators [lymphocyte subsets (CD3, CD4, CD8, CD4/CD8), immunoglobulin M (IgM), immunoglobulin G (IgG), immunoglobulin A (IgA), and complement C3, C4] and arthritis antibodies [anti-keratin antibody (AKA), anti-perinuclear factor (APF), anti-cyclic citrullinated peptide antibody (ACPA), rheumatoid factor (RF)-IgG] were compared among different groups. 【Results】 The levels of CD3, CD4 and the ratio of CD4/CD8 in the systemic type group were significantly higher than those in the polyarticular type group and oligoarticular type group (P<0.05), and the level of CD8 was significantly lower than that in the polyarticular type group and oligoarticular type group (P<0.05); the level of CD8 in the polyarticular type group was significantly lower than that in the oligoarticular type group (P<0.05). The levels of IgG, IgM and IgA in the systemic type group were significantly higher than those in the oligoarticular type group (P<0.05), and the levels of C3 and C4 were significantly higher than those in the polyarticular type group and oligoarticular type group (P<0.05); the levels of IgG, IgM and IgA in the polyarticular type group were significantly higher than those in the oligoarticular type group (P<0.05). The positive rates of AKA, ACPA, APF and RF-IgG in the systemic type group were lower than those in the polyarticular type group, with statistically significant differences (P<0.05); the positive rates of AKA, ACPA and APF in the polyarticular type group were higher than those in the oligoarticular type group, with statistically significant differences (P<0.05). 【Conclusion】 There are significant differences in the degree of immune dysfunction and the positive rate of arthritis antibodies in children with different subtypes of juvenile idiopathic arthritis, which may be related to their different pathogenesis.

Key words： Arthritis, Juvenile Immunoassay Antibodies

Received: 22 October 2025

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R452

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	WANG Ying
	QI Yaru

Cite this article:

WANG Ying,QI Yaru. Comparison of Immunity and Arthritis Antibodies in Children with Different Subtypes of Juvenile Idiopathic Arthritis[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(3): 439-441.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.03.024 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I3/439

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