应用右美托咪定对下肢骨折患儿术后应激反应及脑组织氧代谢的影响

doi:10.3969/j.issn.1671-7171.2026.03.023

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Abstract 【Objective】 To investigate the effects of dexmedetomidine (Dex) on postoperative stress response and cerebral oxygen metabolism in children undergoing surgery for lower limb fractures. 【Methods】 A total of 86 children scheduled for lower limb fracture surgery were randomly assigned to an observation group or a control group, with 43 cases in each group. The observation group received Dex before anesthesia induction, while the control group was intravenously injected with an equal volume of normal saline. Surgical conditions, stress response indices, neurological function indices, cerebral oxygen metabolism parameters, and the incidence of adverse reactions before and after surgery were compared between the two groups. 【Results】 The times to recovery of spontaneous respiration, recovery of consciousness, and extubation were significantly shorter in the observation group than in the control group (P<0.05). At 1 h postoperatively, the visual analogue scale (VAS) score was lower and the Ramsay score was higher in the observation group than in the control group (P<0.05). Postoperatively, malondialdehyde (MDA) levels increased in both groups compared with preoperative levels (P<0.05), but the MDA level in the observation group was lower than that in the control group (P<0.05). Superoxide dismutase (SOD) and heme oxygenase-1 (HO-1) levels decreased in both groups after surgery, but they both were higher in the observation group than in the control group (P<0.05). Levels of glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and S100β protein were higher postoperatively in both groups (P<0.05), but they were lower in the observation group than in the control group (P<0.05). The cerebral oxygen extraction ratio (CERO₂), jugular venous oxygen content (CjvO₂), and arterial oxygen content (CaO₂) decreased postoperatively in both groups (P<0.05). Compared with the control group, the observation group showed higher CaO₂ and CjvO₂ levels but a lower CERO₂ level (P<0.05). There were no significant differences in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 The intraoperative application of Dex in children undergoing lower limb fracture surgery provides favorable anesthetic effects, has minimal impact on postoperative stress response and neurological function, improves postoperative cerebral oxygen metabolism, and demonstrates good safety.

Key words： Bones of Lower Extremity Fractures Dexmedetomidine Stress, Physiological Child

Received: 15 December 2024

PACS:

R726.83

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	Articles by authors
	SHAN Chengjing
	PENG Bei
	WU Xiaole
	YANG Chen

Cite this article:

SHAN Chengjing,PENG Bei,WU Xiaole, et al. Effects of Dexmedetomidine on Postoperative Stress Response and Cerebral Oxygen Metabolism in Children with Lower Limb Fractures[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(3): 435-438.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.03.023 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I3/435

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