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| Clinical Efficacy of Xanthium Rhinitis Dripping Pills Combined with Cefuroxime in the Treatment of Patients with Acute Sinusitis |
| SHAO Hong |
| Department of Pharmacy,the Fifth Clinical College of Henan University of Chinese Medicine(Zhengzhou People's Hospital), Zhengzhou Henan 450000 |
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Abstract 【Objective】 To explore the clinical efficacy of Xanthium Rhinitis Dripping Pills combined with cefuroxime in the treatment of patients with acute sinusitis. 【Methods】 A total of 101 patients with acute sinusitis admitted to our hospital from March 2023 to March 2025 were selected and divided into a control group(n=51, treated with cefuroxime plus placebo with identical appearance) and an observation group(n=50, treated with cefuroxime plus Xanthium Rhinitis Dripping Pills) using a computer-generated random sequence(completed by an independent statistician). During the study period, 3 cases in the control group(2 lost to follow-up, 1 withdrew voluntarily) and 2 cases in the observation group(lost to follow-up) dropped out, and finally 96 cases completed all follow-up visits(48 cases in each group). The clinical efficacy, inflammatory indicators, nasal endoscopy scores(Lund-Kennedy scores), clinical symptoms and incidence of adverse reactions were compared between the two groups. 【Results】 The total effective rate of the observation group was higher than that of the control group(P<0.05). After treatment, the serum levels of hypersensitive C-reactive protein(hs-CRP) and procalcitonin(PCT) in the observation group were lower than those in the control group(P<0.05), and the Lund-Kennedy scores and the scores of all dimensions of the Sinonasal Outcome Test-20(SNOT-20) in the observation group were lower than those in the control group(P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】 Xanthium Rhinitis Dripping Pills combined with cefuroxime can improve the clinical efficacy of patients with acute sinusitis, alleviate the inflammatory response, and has good safety, which is worthy of clinical promotion and application.
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Received: 11 August 2025
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