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| Diagnostic Value of Quantitative Detection of EBV-DNA in Bronchoalveolar Lavage Fluid for Transplant-Related Pulmonary Infection |
| XU Chengyu, HAN Qingzhen, ZHUANG Zi, et al |
| Department of Clinical Testing Center, The Fourth Affiliated Hospital of Soochow University(Suzhou Dushu Lake Hospital), Suzhou Jiangsu 215000 |
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Abstract 【Objective】 To explore the diagnostic value of quantitative detection of Epstein-Barr virus(EBV)-DNA in bronchoalveolar lavage fluid(BALF) for transplant-related pulmonary infection.【Methods】 A retrospective analysis was conducted on 912 clinical samples from patients with transplant-related pulmonary infection admitted to our hospital from May 2023 to October 2024, including 624 whole blood samples and 288 BALF samples. Among them, 163 patients submitted both whole blood samples and BALF samples for testing. The EBV positive rate, EBV-DNA load of the two types of samples, as well as the EBV positive rate and EBV-DNA load in different clinical groups(hematological disease transplantation group, hematological disease non-transplantation group, non-hematological disease group) were compared.【Results】 The EBV positive rate and EBV-DNA load of BALF samples were significantly higher than those of whole blood samples(P<0.01). The EBV positive rate of BALF in the hematological disease transplantation group(59.13%) was significantly higher than that in the non-transplantation group(28.95%) and the non-hematological disease group(50.00%)(P=0.0054).【Conclusion】 The detection of EBV-DNA in BALF samples has higher diagnostic sensitivity than that in whole blood samples. It is especially suitable for the early identification and dynamic monitoring of pulmonary infection after hematological disease transplantation, and can provide an important basis for clinical precise intervention.
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Received: 28 May 2025
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2025, Vol. 42 
