|
|
|
| Correlation Analysis of Peripheral Inflammatory Cytokine Levels and Unstable Angina Pectoris |
| ZHANG Jinwei, ZHOU Qian |
| Nanyang Central Hospital, Nanyang Henan 473000 |
|
|
|
|
Abstract 【Objective】To investigate the correlation between serum levels of human chondroitin sulfate proteoglycan 40 (YKL-40), high-sensitivity C-reactive protein (hs-CRP), interleukin-17 (IL-17), interleukin-23(IL-23),interleukin-1β(IL-1β), and tumor necrosis factor-α (TNF-α) and unstable angina pectoris (UAP). 【Methods】Eighty-seven UAP patients (UAP group), 60 stable angina pectoris (SAP) patients (SAP group), and 52 healthy controls with normal coronary angiography results during the same period were enrolled from January 2022 to January 2024. Serum levels of YKL-40, hs-CRP, IL-17, IL-23, IL-1β, and TNF-α were compared across groups. The predictive efficacy of these cytokines for UAP was evaluated using receiver operating characteristic (ROC) curves. 【Results】Serum levels of YKL-40, hs-CRP, IL-17, IL-23, IL-1β, and TNF-α were significantly higher in the UAP group than in the SAP group and control group (P<0.05), and significantly higher in the SAP group than in the control group (P<0.05). All cytokines showed certain predictive efficacy for UAP (P<0.05), with areas under the curve (AUC) of 0.903, 0.891, 0.773, 0.801, 0.756, and 0.736, respectively.【Conclusion】 YKL-40, hs-CRP, IL-17, IL-23, IL-1β, and TNF-α may be involved in the progression of UAP and could serve as serum markers for UAP prediction.
|
|
Received: 15 March 2024
|
|
|
|
|
|
[1] OGATA S, MARUME K, NAKAI M, et al. Incidence rate of acute coronary syndrome including acute myocardial infarction, unstable angina, and sudden cardiac death in nobeoka city for the super-aged society of Japan[J].Circ J,2021, 85(10):1722-1730.
[2] 王凯杰, 朱明林, 吴云, 等. 联合检测血脂、炎性因子在动脉粥样硬化患者中的应用[J].中华实验外科杂志, 2020, 37(1):28.
[3] 张占帅, 秦少强, 王亚玲, 等. 急性心肌梗死患者血清人软骨糖蛋白39、可溶性肿瘤坏死因子受体1水平与心功能及预后的相关性[J].中国动脉硬化杂志, 2022, 30(3):243-247.
[4] 张正琰, 蒋永兴, 田野. 动脉粥样硬化炎症及其影像学评价方法[J].中国循环杂志, 2021, 36(5):516-520.
[5] 中华医学会心血管病学分会介入心脏病学组, 中华医学会心血管病学分会动脉粥样硬化与冠心病学组, 中国医师协会心血管内科医师分会血栓防治专业委员会, 等. 稳定性冠心病诊断与治疗指南[J].中华心血管病杂志, 2018, 46(9):680-694.
[6] 中国医师协会急诊医师分会, 中华医学会心血管病学分会, 中华医学会检验医学分会. 急性冠脉综合征急诊快速诊疗指南[J].中华急诊医学杂志, 2016, 25(4):397-404.
[7] PEDRO-BOTET J, CLIMENT E, BENAIGES D. Atherosclerosis and inflammation. new therapeutic approaches[J].Med Clin (Barc),2020, 155(6):256-262.
[8] BUGGER H, ZIRLIK A. Anti-inflammatory strategies in atherosclerosis[J].Hamostaseologie,2021, 41(6):433-442.
[9] KULKARNI N B, GANU M U, GODBOLE S G, et al. Assessment of potential biomarkers of atherosclerosis in Indian patients with type 2 diabetes mellitus[J].Indian J Med Res,2018, 147(2):169-176.
[10] SCIBORSKI K, KULICZKOWSKI W, KAROLKO B, et al. Plasma YKL-40 levels correlate with the severity of coronary atherosclerosis assessed with the SYNTAX score[J].Pol Arch Intern Med,2018, 128(11):644-648.
[11] MA C Y, XU Z Y, WANG S P, et al. Change of inflammatory factors in patients with acute coronary syndrome[J].Chin Med J (Engl),2018, 131(12):1444-1449.
[12] 张宁, 刘文娴, 康云鹏. 血浆超敏C-反应蛋白与白蛋白比值对急性冠脉综合征患者死亡的预测价值[J].中华危重病急救医学, 2021, 33(5):573-577.
[13] 李欣, 赵玉玲, 周树龙, 等. 不稳定型心绞痛患者血清CTRP1水平变化及临床意义[J].重庆医学, 2019, 48(2):259-262.
[14] FRIEDER J, KIVELEVITCH D, HAUGH I, et al. Anti-IL-23 and Anti-IL-17 biologic agents for the treatment of immune-mediated inflammatory conditions[J].Clin Pharmacol Ther,2018, 103(1):88-101.
[15] 黄珊, 杨洋, 孟庆雯, 等. IL-23/IL-17炎症轴与冠心病及动脉粥样硬化的关系[J].中国老年学杂志, 2019, 39(8):1800.
[16] XU Y, YE J, WANG M L, et al. The expression of interleukin-25 increases in human coronary artery disease and is associated with the severity of coronary stenosis[J].Anatol J Cardiol,2020, 23(3):151-159. |
|
|
|
2025, Vol. 42 
