脐血瘦素、IGFBP-3水平与妊娠期糖尿病孕妇分娩巨大儿的相关性分析

doi:10.3969/j.issn.1671-7171.2025.04.018

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Abstract 【Objective】To explore the correlation between the levels of leptin and insulin-like growth factor binding protein 3 (IGFBP-3) in umbilical cord blood and the delivery of macrosomia in pregnant women with gestational diabetes mellitus (GDM). 【Methods】 A total of 312 pregnant women with GDM who delivered in our hospital from April 2020 to June 2023 were selected. The pregnant women were divided into Group A (macrosomia, neonatal birth weight ≥4 kg) and Group B (non-macrosomia, neonatal birth weight normal or lower than normal weight) according to the birth weight of the newborns. The levels of leptin and IGFBP-3 in umbilical cord blood before delivery were compared between the two groups. We analyzed the influencing factors of macrosomia delivery in pregnant women with GDM to explore the correlation of macrosomia delivery in pregnant women with GDM with umbilical cord blood levels of leptin and IGFBP-3. The predictive value of umbilical cord blood leptin and IGFBP-3 levels for macrosomia delivery in pregnant women with GDM was evaluated. 【Results】The levels of IGFBP-3, umbilical cord blood leptin and fasting blood glucose in group A were all higher than those in group B (P<0.05). The results of binary Logistic regression analysis showed that higher levels of fasting blood glucose, umbilical cord blood leptin, and IGFBP-3 were risk factors for pregnant women with GDM to deliver macrosomia (P<0.05). The results of the receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of the combined prediction of umbilical cord blood leptin, IGFBP-3, and fasting blood glucose for the delivery of macrosomia in pregnant women with GDM was higher than that of the single index detection (P<0.05). The results of the correlation analysis showed that umbilical cord blood leptin and IGFBP-3 were positively correlated with the delivery of macrosomia in pregnant women with GDM(P<0.05).【Conclusion】The combined detection of fasting blood glucose, umbilical cord blood leptin, and IGFBP-3 has a high predictive value for the delivery of macrosomia in pregnant women with GDM.

Key words： Diabetes Gestational Leptin Insulin-Like Growth Factor Binding Protein 3 Correlation of Data

Received: 09 May 2024

PACS:

R714.256

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	Articles by authors
	DAI Jingfang
	ZHANG Dongmei
	ZHANG Qian

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DAI Jingfang,ZHANG Dongmei,ZHANG Qian. Correlation Analysis of Macrosomia with Gestational Diabetes Mellitus with Cord Blood Leptin and IGFBP-3 Levels[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(4): 623-625.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.04.018 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I4/623

[1] 杨淑娟,刘俐,罗岳西,等.妊娠期糖尿病患者血清丙二醛、CA-125水平与糖脂代谢及妊娠结局关系[J].中国计划生育学杂志, 2022, 30(8):1852-1855.
[2] 张素芹,姜萍,赵明瑜,等.妊娠期糖尿病并发子痫前期患者胎盘组织抵抗素、人脂质运载蛋白及血糖脂代谢检测价值[J].中华内分泌外科杂志, 2022, 16(5):627-632.
[3] 陈玉荣,段小凯,刘春凡,等.2014—2018年郑州市某医院妊娠期糖尿病巨大儿发生影响因素和妊娠结局分析[J].中华全科医学, 2021, 19(6):959-963.
[4] 田华,周红芬.血清胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3在特发性矮小患儿中的表达和意义[J].中国妇幼保健, 2021, 36(23):5471-5474.
[5] 喻荷淋,吴艳,蒋莉,等.妊娠期糖尿病患者脐血成纤维细胞生长因子19、瘦素水平与新生儿出生体重的关系[J].实用医院临床杂志, 2021, 18(1):41-43.
[6] 杨志芬,王春洋.2021年妊娠期糖尿病相关诊疗指南解读[J].河北医科大学学报,2021,42(9):993-997.
[7] 申素芳,靳双玲.妇产科学[M].3版.北京:人民军医出版社,2009:102-110.
[8] 魏君香,米阳,罗肖,等.单纯空腹血糖升高妊娠期糖尿病孕妇不良妊娠结局及其影响因素研究[J].中国全科医学, 2022, 25(26):3270-3280.
[9] 陈婷婷,唐红浩,尤祥妹,等.孕早期医学营养治疗在妊娠期糖尿病高危孕妇糖脂代谢及孕期体质量管理中的应用效果[J].中国妇幼保健, 2023, 38(3):419-423.
[10] 张苏丽,张小兰,胡燕.妊娠期糖尿病孕妇葡萄糖耐量试验后血糖升高速率与胰岛素分泌及不良妊娠结局关系[J].中国计划生育学杂志, 2022, 30(3):672-676.
[11] 卢丹,祝淡抹,单委,等.胰岛素样生长因子和胰岛素样生长因子结合蛋白-3与胎儿生长受限的关系[J].中国医药科学, 2021, 11(4):9-12.
[12] 黄宝丰,陈文博,蒋科威,等.老年住院病人血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与衰弱的相关性研究[J].实用老年医学, 2022, 36(1):57-60.
[13] 栗慧芳,宋肖肖,李燕,等.云南省某地区农村妇女孕期被动吸烟对新生儿脐血瘦素及出生体重的影响[J].环境与职业医学, 2023,40(7):805-810.