Abstract 【Objective】To explore the clinical efficacy of vitamin B12 and folic acid in the treatment of megaloblastic anemia (MA) patients.【Methods】Clinical data of 50 MA patients treated with vitamin B12 and folic acid supplementation were collected. The patients' clinical manifestations, changes in hematological indicators, and treatment outcomes were analyzed.【Results】After treatment, the mean corpuscular volume (MCV) of the patients decreased, while hemoglobin (Hb), vitamin B12, and folic acid levels increased significantly compared to before treatment, with differences being statistically significant (P<0.05). The proportion of patients with symptoms such as fatigue, pallor, loss of appetite, weight loss, and neurological symptoms significantly decreased after treatment, with differences being statistically significant (P<0.05). Correlation analysis showed that vitamin B12 had the closest association with symptom improvement. Vitamin B12, folic acid, and Hb levels were negatively correlated with fatigue, pallor, loss of appetite, weight loss, and neurological symptoms (all P<0.05). MCV was positively correlated with the above symptoms (P<0.05).【Conclusion】Supplementation of vitamin B12 and folic acid can improve hematological indicators and clinical symptoms in MA patients, which vitamin B12 plays a key role in symptom improvement. When diagnosing and treating MA clinically, attention should be paid to the detection and supplementation of vitamin B12 levels.
SUN Xingwei. Clinical Efficacy of Vitamin B12 and Folic Acid in the Treatment of Megaloblastic Anemia Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 255-257.
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