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| Effect of Metoprolol Combined with Early Reperfusion Therapy within 24 Hours after PCI on Cardiac Function and Prognosis of Acute Myocardial Infarction Patients |
| HU Zhenhua, WANG Shouyang, LIU Xuerui |
| Huaxian People's Hospital, Huaxian Henan 456400 |
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Abstract 【Objective】To investigate the effect of metoprolol combined with early reperfusion therapy within 24 hours after percutaneous coronary intervention (PCI) on the cardiac function and prognosis of patients with acute myocardial infarction (AMI). 【Methods】 A total of 168 AMI patients admitted to the Department of Cardiology, Huaxian People's Hospital from August 2022 to October 2024 were selected, all of whom received early reperfusion therapy after PCI. Based on treatment methods, the patients were divided into a control group (early reperfusion therapy) and an observation group (administration of metoprolol within 24 hours after PCI in addition to the control group's treatment), with 84 cases in each group. Myocardial injury markers [heart-type fatty acid-binding protein (h-FABP), procollagen type Ⅲ amino-terminal peptide (PⅢNP), galectin-3 (Gal-3)], autonomic nerve function [heart rate variability (HRV) time-domain SDNN, rMSSD, QT interval dispersion (QTd)], cardiac function indices [left ventricular ejection fraction (LVEF), left ventricular fractional shortening (FS), myocardial salvage index (MSI)], and the incidence of major adverse cardiovascular events (MACE) were compared between the two groups.【Results】At 7 days post-PCI (T1), serum h-FABP, PⅢNP, and Gal-3 levels were lower than preoperative levels (T0) in both groups, with the observation group showing significantly lower levels than the control group (P<0.05). At T1, both groups exhibited increased SDNN and rMSSD compared to T0, while QTd was lower than T0. The observation group had significantly higher SDNN and rMSSD and lower QTd than the control group, with statistically significant differences (P<0.05). At 30 days post-operation, LVEF, FS, and MSI in both control and observation groups were higher than those at 72 hours post-operation of corresponding groups, with the observation group showing significantly higher values than the control group (P<0.05). The MACE incidence rate in the observation group was 7.14% (6/84), which was lower than that in the control group's 14.29% (12/84), with a statistically significant difference (χ2=2.354, P<0.05).【Conclusion】Application of metoprolol combined with early reperfusion therapy within 24 hours after PCI can significantly reduce myocardial injury, improve autonomic nerve function and cardiac function, and decrease the incidence of MACE in AMI patients, contributing to improving their prognosis.
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Received: 20 June 2025
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2025, Vol. 42 
