急性胰腺炎患者血清HMGB1、ICAM-1水平与APACHE Ⅱ、BISAP评分的相关性分析

doi:10.3969/j.issn.1671-7171.2025.01.005

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Abstract 【Objective】To investigate the correlation between serum levels of high mobility group 1 protein (HMGB1) and intercellular adhesion molecule-1 (ICAM-1) in patients with acute pancreatitis with acute physiology and chronic health status evaluation Ⅱ (APACHE Ⅱ) and bedside index of acute pancreatitis severity (BISAP) scores. 【Methods】Eighty patients with acute pancreatitis admitted to our hospital from April 2020 to April 2022 were selected and divided into the mild group (n=39), moderate group (n=23), and severe group (n=18) according to the severity of their condition. Another 80 healthy volunteers who underwent physical examinations in our hospital were selected as the healthy group. Levels of serum HMGB1, ICAM-1, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), as well as APACHE Ⅱ and BISAP scores were compared among the four groups. The correlation of serum HMGB1 and ICAM-1 levels with CRP, TNF-α, IL-6, APACHE Ⅱ score, and BISAP score was analyzed among the four groups. 【Results】The APACHE Ⅱ scores of the four groups were shown in the order of the healthy group<the mild group<the moderate group<the severe group; And the difference was statistically significant (P<0.05). The BISAP scores of the three groups of patients showed an increasing trend with the mild group<the moderate group<the severe group, and the difference was statistically significant (P<0.05). The comparison of serum levels of HMGB1, ICAM-1, CRP, TNF-α, and IL-6 in the four groups showed that the healthy group was least followed by the order of the mild group<the moderate group < the severe group, with statistically significant differences (P<0.05). Pearson correlation analysis showed that serum levels of HMGB1 and ICAM-1 were positively correlated with serum levels of CRP, TNF-α, IL-6, as well as APACHE Ⅱ score and BISAP score (P<0.05). 【Conclusion】The levels of serum HMGB1 and ICAM-1 are correlated with the severity of acute pancreatitis in patients. Clinical physicians can evaluate the severity of patients' condition by detecting the levels of serum HMGB1 and ICAM-1.

Key words： Pancreatitis Acute Disease High Mobility Group Proteins Cell Adhesion Molecules APACHE Ⅱ

Received: 11 April 2023

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R576.1

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	WANG Nijuan
	LIU Jia

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WANG Nijuan,LIU Jia. Correlation Analysis of Serum HMGB1 and ICAM-1 Levels with APACHE Ⅱ and BISAP Scores in Patients with Acute Pancreatitis[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(1): 16-19.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.01.005 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I1/16

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