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| Efficacy of Ambroxol Hydrochloride in Adjuvant Treatment of Neonatal Infectious Pneumonia and its Effect on Arterial Blood Gas and Inflammatory Response |
| LI Yishe |
| Lushi County Hospital for Maternal & Child Health Care,Shanmenxia Henan 472200 |
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Abstract 【Objective】To investigate the clinical efficacy of ambroxol hydrochloride in the adjuvant treatment of neonatal infectious pneumonia and its effect on arterial blood gas and inflammatory response in neonates with infectious pneumonia. 【Methods】A total of 100 children with pneumonia treated in the neonatal department of our hospital from July 2019 to May 2021 were selected as the research objects and randomly divided into the observation group and the control group (with 50 cases in each group). The control group was given conventional anti-infective treatment, while the observation group was given ambroxol hydrochloride in addition to conventional anti-infective treatment. The therapeutic efficacy, clinical symptoms and signs, and changes in arterial blood gas indexes [arterial carbon dioxide partial pressure (PaCO2), arterial oxygen partial pressure (PaO2)] and inflammatory factors [procalcitonin (PCT), tumor necrosis factor (TNF-α), C-reactive protein (CRP)] before and after treatment were compared between the two groups.【Results】The total clinical effective rate of the observation group was higher than that of the control group (P<0.05). At the end of treatment, the daily sputum suction times of the observation group were significantly less than the control group(P<0.05). The average length of hospitalization in the observation group, the disappearance time of cough and asthma, the disappearance time of pulmonary rales and antipyretic time in the observation group were significantly shorter than those in the control group ( all P<0.05). After treatment, PCT, TNF-α and CRP in both groups were lower than those before treatment; And levels of PCT, TNF-α and CRP in the observation group were lower than those in the control group( all P<0.05).At the end of treatment, the levels of PaCO2 in the two groups were decreased (all P<0.05), while PaO2 was increased (all P<0.05). After treatment, the PaO2 level in the observation group was higher, while PaCO2 was lower compared to the control group ( P<0.05). 【Conclusion】Ambroxol hydrochloride adjuvant is effective in the treatment of neonatal infectious pneumonia, which can effectively reduce the levels of inflammatory factors in children and improve their lung function.
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Received: 21 November 2022
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2024, Vol. 41 
