沙库巴曲缬沙坦联合匹伐他汀治疗冠心病合并心力衰竭的临床疗效

doi:10.3969/j.issn.1671-7171.2024.08.029

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Abstract 【Objective】To investigate the clinical efficacy of sacubitril valsartan combined with pitavastatin in the treatment of coronary heart disease (CHD) with heart failure (HF).【Methods】A retrospective analysis was conducted on the clinical data of 82 patients with CHD combined with HF admitted to our hospital from February 2020 to February 2022. According to the treatment method, they were divided into the control group (treated with pitavastatin in addition to conventional treatment) and the observation group (treated with sacubitril in addition to the control group), with 41 patients in each group. Two groups were compared in terms of clinical efficacy, cardiac function indicators [left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD)], 6-minute walk test (6MWT) distance, and quality of life [Minnesota Heart Failure Quality of Life Scale (LHFQ score)], and the incidence of adverse reactions during treatment was statistically analyzed. 【Results】The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, LVEF in both groups was higher than before treatment, while LVEDD and LVESD were lower than before treatment. The differences between the observation group and the control group were statistically significant (P<0.05). After treatment, the distance between the two groups of 6MWT distarce was greater than before treatment, and the LHFQ score was lower than before treatment. Moreover, the difference between the observation group and the control group was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The combination of sacubitril valsartan and pitavastatin has a good therapeutic effect on CHD complicated with HF, significantly improving patients' cardiac function, enhancing their quality of life, and has high safety.

Key words： Coronary Disease Heart Failure Valsartan Hydroxymethylglutaryl-CoA Reductase Inhibitors

Received: 01 August 2023

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R541.4

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.08.029 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I8/1219

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