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| The Correlation between EGFR and Ki-67 Expression and the Prognosis of Radical Surgery for Primary Liver Cancer |
| WANG Xiaojian |
| Nanyang First People's Hospital,Nanyang Henan 473000 |
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Abstract 【Objective】To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) and Ki-67 in cancer tissues and the postoperative prognosis of primary liver cancer (HCC).【Methods】A total of 103 HCC patients admitted to the hospital from June 2015 to June 2018 were selected. All patients underwent HCC radical surgery and postoperative prophylactic transcatheter arterial chemoembolization, and were followed up for 3 years after surgery. We detected and compared the expression of EGFR and Ki-67 in cancer tissues and adjacent tissues, analyzed the relationship between EGFR and Ki-67 expression in cancer tissues and pathological factors, analyzed the factors affecting the prognosis of HCC radical surgery, and analyzed the relationship between EGFR and Ki-67 expression in cancer tissues and postoperative prognosis of HCC.【Results】The positive expression rates of EGFR and Ki-67 in cancer tissues were higher than those in adjacent tissues (P<0.05). The positive expression rates of EGFR and Ki-67 in cancer tissues of patients with microvascular tumor thrombus, incomplete tumor capsule, clinical stage Ⅲ, and low differentiation were higher than those of patients without microvascular tumor thrombus, intact tumor capsule, clinical stage Ⅰ-Ⅱ, and moderately to well differentiated patients (P<0.05). Cox regression analysis showed that microvascular tumor thrombus, tumor capsule, clinical stage, differentiation degree, EGFR expression, Ki-67 expression were related factors affecting disease-free survival rate (P<0.05); Tumor capsule, clinical stage, differentiation degree, EGFR expression, and Ki-67 expression are related factors affecting overall survival rate (P<0.05). The disease-free survival rate and overall survival rate of EGFR and Ki-67 negative expression patients were better than those of positive expression patients, and the differences were statistically significant (P<0.05).【Conclusion】EGFR and Ki-67 are abnormally overexpressed in cancer tissues of HCC patients. EGFR and Ki-67 expression are associated with the pathology and prognosis of HCC patients after surgery, and those with positive expression have a higher risk of poor prognosis.
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Received: 25 June 2023
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2024, Vol. 41 
