惊厥性癫痫持续状态患儿预后不良的影响因素分析

doi:10.3969/j.issn.1671-7171.2024.06.007

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Abstract 【Objective】To explore the influencing factors of poor prognosis in children with convulsive status epilepticus(CSE). 【Methods】A retrospective analysis was conducted on the clinical data of 347 children with CSE admitted to our hospital from March 2018 to September 2021. Based on their prognosis at discharge, they were divided into a good prognosis group(n=279) and a poor prognosis group(n=68). Two sets of general data and serum levels of neuropeptide Y(NPY), procalcitonin(PCT), alanine aminotransferase(ALT), interleukin-6(IL-6), glial fibrillary acidic protein(GFAP), matrix metalloproteinase-9(MMP-9), and galanin(GAL) were compared. A logistic multiple regression model was used to analyze the risk factors affecting poor prognosis in children with CSE. 【Results】The incidence of poor prognosis in 347 children with CSE was 19.60%(68/347). The age and serum levels of NPY, GFAP, MMP-9, and GAL in the group with poor prognosis were compared with those in the group with good prognosis, and the differences were statistically significant(P<0.05). Logistic regression analysis showed that age<2 years, NPY>201.03 ng/L, GFAP>2.63 ng/L, MMP-9>10.69 ng/mL, GAL>67.53 ng/L were risk factors for poor prognosis in children with CSE(P<0.05). 【Conclusion】The adverse factors affecting the prognosis of CSE patients are age and serum levels of NPY, GFAP, MMP-9, and GAL. Clinicians should pay special attention to patients with these factors and provide timely and effective treatment measures.

Key words： Epilepsy Convulsions Prognosis Root Cause Analysis

Received: 06 July 2022

PACS:

R742.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.06.007 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I6/824

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