七氟醚复合麻醉对妇科腹腔镜手术患者血流动力学、疼痛因子水平的影响

doi:10.3969/j.issn.1671-7171.2024.05.027

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1179 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the effects of sevoflurane combined anesthesia on hemodynamics and pain factors in patients undergoing gynecological laparoscopic surgery.【Methods】There were 86 patients with gynecological diseases treated by laparoscopic surgery in our hospital and random divided into the observation group and the control group (n=43).The control group received propofol combined anesthesia, and the observation group received sevoflurane combined anesthesia. The anesthesia effects, heart rate (HR), mean arterial pressure (MAP) and other hemodynamic indicators before induction (T₀), intubation (T₁), intubation 5 min (T₂), skin incision (T₃), post-pneumoperitoneum (T₄), and extubation (T₅) were compared between the two groups. Serum levels of pain factors such as 5-HT, PGE₂, β-endorphin (β-EP) and substance P (SP) at 6 h, 12 h and 24 h postoperatively, and the occurrence of postoperative adverse reactions of the two groups was compared as well.【Results】There was no difference in anesthesia time between the two groups (P>0.05).The recovery time of spontaneous breathing, eye opening time, language response time, recovery time of orientation and extubation time in observation group were shorter than those in control group (P<0.05). At T₃, HR of observation group was higher than that of control group at the same point (P<0.05). At T₂, T₃ and T₄, the MAP of observation group was higher than that of control group (P<0.05). There were no differences in HR and MAP between the two groups at other time points (P>0.05). There were no differences in the incidence of 5-HT, PGE₂, β-EP, SP and adverse reactions between two groups before and after operation (P>0.05).【Conclusion】sevoflurane combined anesthesia can maintain hemodynamic stability, promote postoperative resuscitation and effectively regulate pain factors in patients undergoing gynecological laparoscopic surgery, and the incidence of adverse reactions is low.

Key words： Sevoflurane Laparoscopy Gynecologic Surgical Procedures Hemodynamics Anesthesia

Received: 20 January 2023

PACS:

R713

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TANG Hui
	HUANG Wei
	LI Bin
	et al

Cite this article:

TANG Hui,HUANG Wei,LI Bin, et al. Effects of Sevoflurane Combined Anesthesia on Hemodynamics and Pain Factors in Patients Undergoing Gynecological Laparoscopic Surgery[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(5): 739-742.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.05.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I5/739

[1] 蒋芳, 向阳. 腹腔镜在妇科肿瘤手术中的应用进展[J].实用妇产科杂志, 2022, 38(3): 165-168.
[2] 徐蕊, 崔燕, 雷黎明. 气管插管全身麻醉对妇科腹腔镜手术患者血流动力学指标、激素及血气状态的影响研究[J].临床和实验医学杂志, 2021, 20(7): 776-779.
[3] 高海艳. 右美托咪定对七氟醚吸入麻醉妇科腹腔镜手术患者血流动力学及不良反应的影响[J].检验医学与临床, 2018, 15(5): 692-695.
[4] 黄杰, 李玉, 周维纲, 等. 右美托咪定不同麻醉给药方式在妇科腹腔镜手术中的临床效果[J].贵州医药, 2021, 45(12): 1890-1891.
[5] LEE B, KIM M H, KONG H J, et al. Effects of remimazolam vs. sevoflurane anesthesia on intraoperative hemodynamics in patients with gastric cancer undergoing robotic gastrectomy: a propensity score-matched analysis[J].J Clin Med,2022, 11(9): 2643.
[6] DELLA CORTE L, MERCORIO A, MORRA I, et al. Spinal anesthesia versus general anesthesia in gynecological laparoscopic surgery: a systematic review and meta-analysis[J].Gynecol Obstet Invest,2022, 87(1): 1-11.
[7] GUNUSEN I, AKDEMIR A, SARGN A, et al. The effects of CO₂ pneumoperitoneum at different temperature and humidity on hemodynamic and respiratory parameters and postoperative pain in gynecological laparoscopic surgery: A prospective randomized controlled study[J].Asian J Surg,2022, 45(1): 154-161.
[8] 罗海鸣, 金善良, 全宗宗. 多模式镇痛方案对妇科腹腔镜手术患者的镇痛效果及血流动力学变化、炎性因子的影响[J].医学临床研究, 2020, 37(7): 968-970.
[9] BANSAL T, SINGHAL S, KUNDU K. Prospective randomized double-blind study to evaluate propofol and combination of propofol and sevoflurane as maintenance agents in reducing postoperative nausea and vomiting in female patients undergoing laparoscopic surgery[J].Med Gas Res,2022, 12(4): 137-140.
[10] SUO X Y, WANG Z F, ZHU Y F. Application effect of sevoflurane combined with remifentanil intravenous inhalation anesthesia in patients undergoing laparoscopic radical resection of cervical cancer[J].Am J Transl Res,2022, 14(2): 1034-1042.
[11] 谭美云, 曾伟, 幸泽艇, 等. 不同孕酮水平的妇科腹腔镜手术患者瑞芬太尼靶控输注联合七氟醚吸入麻醉效能比较[J].山东医药, 2022, 62(8): 57-60.
[12] LEE J H, KIM W. Involvement of serotonergic system in oxaliplatin-induced neuropathic pain[J].Biomedicines,2021, 9(8): 970.
[13] 孙慧芳, 匡燕, 罗海鸣, 等. 舒芬太尼联合地佐辛术后自控静脉镇痛对腹腔镜胃癌根治术患者疼痛应激和T细胞亚群的影响[J].现代生物医学进展, 2022, 22(1): 63-67.
[14] 邱凯莎, 黎霭云, 徐秀娟. 帕瑞昔布钠对腹腔镜下阑尾切除术患者术后疼痛及血清β-内啡肽、HSP70、IL-6水平的影响[J].中国医师杂志, 2019, 21(2): 258-260.
[15] LOPES A, SELIGMAN MENEZES M, ANTONIO MOREIRA DE BARROS G. Chronic postoperative pain: ubiquitous and rcely appraised: narrative review[J].Braz J Anesthesiol,2021, 71(6): 649-655.