Abstract 【Objective】To investigate the efficacy of dual antiplatelet therapy in patients with acute cerebral infarction (ACI) associated with H-type hypertension.【Methods】 A total of 100 patients with H-type hypertension related ACI, who received treatment in our hospital, were randomly divided into an observation group and a control group, with 50 patients in each group. Both groups received conventional ACI treatment. The control group was treated with aspirin enteric-coated tablets for antiplatelet therapy, while the observation group received a combination of clopidogrel hydrogen sulfate tablets in addition to the control group's treatment. Both groups maintained the treatment for 8 weeks. The NIH Stroke Scale (NIHSS) scores before and after treatment, the modified Rankin Scale (mRS) scores after treatment, platelet-related parameters, clinical efficacy, and drug-related adverse events were compared between the two groups.【Results】After treatment, the NIHSS scores of both groups were significantly lower than before treatment (P<0.05), and the observation group had even lower scores than the control group (P<0.05). The total effective rate of treatment in the observation group was higher than that in the control group (P<0.05). The mRS scores of patients in the observation group were lower than those in the control group after treatment (P<0.05).Compared with before treatment, the levels of homocysteine (Hcy), mean platelet volume (MPV), and platelet distribution width (PDW) significantly decreased in both groups after treatment (P<0.05), and the levels of Hcy, MPV, and PDW in the observation group were significantly lower than those in the control group after treatment (all P<0.05).There was no significant difference in the total incidence of bleeding between the observation group and the control group (P>0.05).【Conclusion 】The combination of aspirin and clopidogrel hydrogen sulfate tablets for the treatment of ACI patients with concurrent H-type hypertension can reduce neurological deficits, improve the treatment effective rate, and is relatively safe.
BAI Guanbing,PAN Bo,PAN Na. Efficacy of Dual Antiplatelet Therapy in Patients with Acute Cerebral Infarction and H-type Hypertension[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 540-543.
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2024, Vol. 41 
