Abstract 【Objective】To evaluate the feasibility of ultrasonic backscattering method in measuring cancellous bone mineral density parameters of pregnant women by comparing with ultrasonic transmission method. 【Methods】A total of 235 cases of pregnant women were enrolled in this study from June 2017 to July 2018,who came to Shanghai Changing Maternity and Infant Health Hospital for routine examinations. All cases underwent measuring of bone mineral density(BMD) and speed of sound(SOS) by both ultrasonic backscattering method and ultrasonic transmission method. BMD and SOS were compared between the two method groups. All cases were divided into three study groups in terms pregnant phases: first trimester group(<14 gestational weeks),second trimester group(14～28 gestational weeks)and third trimester group(>28 gestational weeks).Both BMD and SOS obtained by ultrasonic backscattering method were compared among the three groups. 【Results】There were no statistic differences of cancellous bone BMD and SOS obtained either by ultrasonic backscattering method or by ultrasonic transmission method(P>0.05). The cancellous bone BMD and SOS values measured by ultrasonic backscattering method of first trimester group were significantly higher than those of second and third trimester group (P<0.05),and the BMD and SOS values of second trimester group were significantly higher than those of third trimester group (P<0.05). 【Conclusion】Cancellous bone BMD and SOS obtained by ultrasonic backscattering method showed no statistic differences from those detected by ultrasonic transmission method. Ultrasonic backscattering method can be used in bone mineral density monitoring in pregnant women, which reflect the changes in different gestational trimesters.
BAI Bo,ZHOU Yuqing,TA Dean. Application Value of Ultrasonic Backscattering Method in Bone Mineral Density Measurement of Cancellous Bone in Pregnant Women[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 185-187.
[1] GLÜER C C. Quantitative ultrasound- It is time to focus research efforts[J].Bone,2007, 40(1): 9-13.
[2] 刘海艳,陈磊,马瑶,等.妊娠期糖尿病对初次妊娠及再次妊娠骨密度的影响[J].中国骨质疏松杂志,2017,23(5):631-634.
[3] 韩海杰,王文斌,许凯亮,等.超声表观积分背散射系数与骨矿密度的相关性分析[J].声学技术,2013,32(1):29-32.
[4] 徐峰,许怿文,刘成成,等.松质骨超声背散射信号的谱信息熵判断方法[J].声学学报,2016,12(3):281-286.
[5] LASHKARI B, YANG L, MANDELIS A.The application of backscattered ultrasound and photoacoustic signals for assessment of bone collagen and mineral contents[J].Quant Imag Med Surg,2015,5(1):46-56.
[6] 王文斌,郭佳林,他得安,等.超声表观积分背散射系数评价新生儿骨状况的可行性研究[J].声学学报,2012,37(2):177-180.
[7] LIU C C, XU F,TA D A,et al.Measurement of the human calcaneus in vivo using ultrasonic backscatter spectral centroid shift[J].J Ultras Med,2016,35(10):2197-2208.
[8] LI Y, LI B, XU F,et al.Ultrasonic backscatter measurements at the calcaneus: An in vivo study[J].Measurement,2018,122:128-134.
[9] 周毓青,白博,他得安.超声背散射法评估松质骨的营养状况[J].南京医科大学学报(自然科学版),2019,39(9):1353-1355.
[10] 杨芳,薛慧平,邓通洋,等.妊娠期超声骨密度异常变化及其影响因素探讨[J].浙江医学,2017,39(10):848-850.
[11] 杨明芳,马瑶,贾红梅,等.早孕期骨密度正常妇女产褥期骨密度分析[J].中国骨质疏松杂志,2017,23(1):66-68.
[12] CALERO J A, CURIEL M D,MORO M J,et al.Speed of sound, bone mineral density and bone strength in ooforectomized rats[J].Eur J Clin Invest,2000,30(3):210-214.
[13] SOWERS M F, SCHOLL T, HARRIS L,et al.Bone loss in adolescent and adult pregnant women[J].Obstet Gynecol,2000,96(2):189-193.
[14] YONEYAMA K,IKEDA J.The effects of dietary calcium and protein intake on changes in bone mineral density during early and late stages of pregnancy[J].Nihon Koshu Eisei Zasshi,2010,57(10):871-880.
[15] 王妍,唐桂娥,陶彩霞. 子痫前期孕妇骨密度的影响因素分析[J].医学临床研究,2019,36(8):1525-1527.
[16] 姚桂蓉,郑剑兰. 孕期补钙预防妊娠期高血压[J].医学临床研究,2008,25(12):2259-2261.
2024, Vol. 41 
