雷珠单抗联合不同剂量维替泊芬光动力疗法治疗CSC合并CNV的临床疗效<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2024.02.005

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Abstract 【Objective】To explore the clinical efficacy of ranibizumab combined with different doses of vitipofen photodynamic therapy in the treatment of chronic central serous chorioretinopathy (CSC) with choroidal neovascularization (CNV). 【Methods】A total of 103 patients with chronic CSC complicated with CNV admitted to Jiading District Central Hospital affiliated with Shanghai Health Medical College from February 2014 to December 2019 were selected. According to different treatment methods, they were divided into a conventional group [58 cases, 58 eyes, treated with ranibizumab and low-dose (1 mg/m²) Vitipofen photodynamic therapy] and an observation group [55 cases, 55 eyes, treated with ranibizumab and half dose (3 mg/m²) Vitipofen photodynamic therapy]. We compared the clinical efficacy, incidence of adverse reactions, height of subretinal fluid protrusion (HPSF), best corrected visual acuity (BCVA), and hemodynamic parameters of the central retinal vein (V_max and V_min) between two groups of patients before and after treatment. 【Results】The total effective rate of the observation group was higher than that of the control group (P<0.05). Before treatment, there was no statistically significant difference in HPSF and BVCA between the two groups of patients (P>0.05);After treatment, HPSF was decreased in both groups, and the observation group was lower than the conventional group (P<0.05). After treatment, BCVA increased in both groups, and the observation group was higher than the conventional group (P<0.05). Before treatment, there was no statistically significant difference in V_max and V_min between the two groups of patients (P>0.05); After treatment, V_max and V_min decreased in both groups of patients, and the observation group was lower than the control group (P<0.05). In the conventional group, there was 1 case of elevated intraocular pressure, 2 cases of nausea and vomiting, and the incidence of adverse reactions was 5.17%; In the observation group, there were 2 cases of elevated intraocular pressure, 2 cases of nausea and vomiting, and the incidence of adverse reactions was 7.27%. There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The combination of ranibizumab and half dose vitipofen photodynamic therapy had a significant effect on the treatment of chronic CSC complicated with CNV. It can improve the visual acuity and central retinal vein hemodynamic indicators of patients, and is safe and reliable.

Key words： Antibodies, Monoclonal/TU Central Serous Chorioretinopathy/TH Photochemotherapy Treatment Outcome

Received: 19 October 2023

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R774.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.02.005 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I2/174

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