肾功能指标在慢性阻塞性肺病患者外周血中的水平变化及其意义

doi:10.3969/j.issn.1671-7171.2024.12.031

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1258 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the expression levels and significance of renal function indicators such as uric acid (UA), creatinine (Cr), cystatin C(cys C) and B-type brain natriuretic peptide (BNP) in peripheral blood of patients with chronic obstructive pulmonary disease (COPD). 【Methods】 A total of 96 patients with COPD admitted to our hospital from May 2020 to June 2022 were selected, including 45 patients in the acute stage (acute group) and 51 patients in the stable stage (stable group). In addition, 90 healthy volunteers who came to our hospital for physical examination during the same period were selected as the control group. The basic data and UA, Cr, cys C and BNP levels of the three groups were compared. Patients in the acute stage were divided into mild group (n=16), moderate group (n=16) and severe group (n=13) according to the degree of airflow limitation. The levels of UA, Cr, cys C and BNP in the three groups were compared, and the correlation between the levels of UA, Cr, cys C and BNP and the degree of airflow limitation in the acute stage was analyzed. 【Results】Compared with the control group, the smoking history ratio of the acute group and stable group was significantly increased, and the difference was statistically significant (P<0.05). The levels of UA, Cr, cys C and BNP in the acute group, the stable group and the control group were decreased successively, and the differences among groups were statistically significant (P<0.05). The levels of UA, Cr, cys C and BNP in severe group, moderate group and mild group were decreased successively, and the differences among groups were statistically significant (P<0.05). Spearman correlation analysis showed that the levels of UA, Cr, cys C and BNP were positively correlated with the degree of airflow restriction in acute patients (P<0.05). 【Conclusion】The abnormal expression levels of UA, Cr, cys C and BNP in peripheral blood of patients with COPD are significantly correlated with the severity of COPD.

Key words： Pulmonary Disease,Chronic Obstructive Kidney Function Tests

Received: 12 July 2024

PACS:

R563.9

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HONG Weihuang
	ZHANG Xieying
	MA Yilong

Cite this article:

HONG Weihuang,ZHANG Xieying,MA Yilong. The Expression Level and Significance of Renal Function Index in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(12): 1934-1936.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.12.031 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I12/1934

[1] OGAN N, GÜNAY E, BAHA A,et al. The effect of serum electrolyte disturbances and uric acid level on the mortality of patients with acute exacerbation of chronic obstructive pulmonary disease[J].Turk Thorac J,2020,21(5):322-328.
[2] TANWAR Y, SINGH C, CHAKRABARTY S. Comparison of serum uric acid levels in patients with stable chronic obstructive pulmonary disease and patients with acute exacerbation[J].J Assoc Physicians India,2022,70(4):11-12.
[3] 蔡晓盛,池琼,吴建华,等. 不同COPD分级患者肾损伤及炎症因子的相关性研究[J].重庆医学,2020,49(4):614-618.
[4] OZANTURK E, UCAR Z Z, VAROL Y, et al. Urinary uric acid excretion as an indicator of severe hypoxia and mortality in patients with obstructive sleep apnea and chronic obstructive pulmonary disease[J].Rev Port Pneumol,2016,22(1):18-26.
[5] DURMUS KOCAK N, SASAK G, AKA AKTURK U, et al.Serum uric acid levels and uric acid/creatinine ratios in stable chronic obstructive pulmonary disease (copd) patients: are these parameters efficient predictors of patients at risk for exacerbation and/or severity of disease[J].Med Sci Monit,2016,22(1):4169-4176.
[6] 朱丽娟,许浦生. 机体尿酸代谢对慢性阻塞性肺疾病患者合并骨质疏松症的影响[J].国际呼吸杂志,2018,38(9):708-711.
[7] 中华医学会,中华医学会杂志社,中华医学会全科医学分会,等. 慢性阻塞性肺疾病基层诊疗指南(2018年)[J].中华全科医师杂志,2018,17(11):856-870.
[8] 阮君,徐建红,庞涛. 稳定性COPD出现AECOPD时血清生物标志物水平的预测价值[J].中国卫生检验杂志,2017,27(23):3422-3424.
[9] 诸海军,孙杰,陈嵩,等. 托拉塞米联合阿托伐他汀对COPD伴急性心力衰竭患者血清hs-CRP、基质金属蛋白酶及尿酸水平的影响[J].临床和实验医学杂志,2021,20(20):2171-2174.
[10] 孙莹,刘长春,郝丽梅,等. RDW、cys C与慢性阻塞性肺疾病患者继发肺动脉高压关系的研究[J].临床输血与检验,2018,20(5):531-533.
[11] 余虹,刘德辉,陈英龙. CA125和cys C水平与慢性阻塞性肺疾病患者肺动脉高压的关系[J].吉林医学,2021,42(4):884.
[12] 吕骁,张宏英,毛雅云,等. BNP、HCAR及D-D在慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭中的变化及与病情、预后的相关性[J].临床误诊误治,2021,34(6):86-91.
[13] 梁彩妮,廖永城,邱宇,等. RDW在COPD患者并发不同程度肺动脉高压的表达及相关性[J].分子诊断与治疗杂志,2020,12(11):1501-1504.
[14] 曹轶,贾振宇. COPD合并Ⅱ型呼吸衰竭预后的影响因素及血清UA、cTnT、NT-proBNP水平预测其预后的价值研究[J].中国医药导报,2022,19(4):95-98.
[15] 刘康珍,覃智芳. 慢性阻塞性肺疾病合并肺部感染患者血清炎症因子、尿酸、NT-proBNP水平与肺功能的相关性研究[J].现代医学,2019,47(6):692-696.