丹红注射液联合依达拉奉右莰醇治疗急性脑梗死的疗效

doi:10.3969/j.issn.1671-7171.2024.12.019

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1201 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To investigate the efficacy of Danhong injection combined with Edaravone dextrocamphorol in the treatment of acute cerebral infarction (ACI). 【Methods】A total of 98 patients with ACI were randomly divided into the observation group and the control group, with 49 cases in each group. The control group was treated with Edaravone dexcamphorol, and the observation group was treated with Danhong injection combined with Edaravone dexcamphorol. The neurological function (NIHSS score) and cognitive function (Mini-mental State Examination, MMES) score, Ubiquitin carboxyl terminal hydrolase L1 (UCH-L1) ,hypersensitive C-reactive protein (hs-CRP) levels and living capacity and adverse reactions of the two groups were compared before and after treatment. 【Results】After treatment, NIHSS score, UCH-L1 level and hs-CRP level in the observation group were lower than those in the control group, and MMES score and life ability score were higher than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 10.20%, which was not statistically significant compared with 8.16% in the control group (P>0.05). 【Conclusion】Danhong injection combined with Edaravone dextrocamphorol is effective in the treatment of ACI patients, which can improve the neurological and cognitive functions of patients, reduce the level of inflammatory factors, and have fewer adverse reactions.

Key words： Brain Infarction Acute Disease Danhong Zhusheye Edaravone Treatment Outcome

Received: 20 November 2023

PACS:

R743.33

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHENG Chunli
	YANG Junling

Cite this article:

ZHENG Chunli,YANG Junling. Curative Effect of Danhong Injection Combined with Edaravone Dextrocamphorol in the Treatment of Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(12): 1893-1895.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.12.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I12/1893

[1] 张亚萍. 急性脑梗死患者发生认知障碍的影响因素[J].河南医学研究,2023,32(3):467-470.
[2] 郝雅文. 急性脑梗死的治疗进展[J].天津药学,2021,33(4):66-69.
[3] 王东阳. 丹红注射液联合丁苯酞胶囊治疗短暂性脑缺血发作的疗效观察[J].基层医学论坛,2023,27(4):66-68.
[4] 刘前,邓倩,周静,等. 依达拉奉右莰醇联合阿托伐他汀治疗老年急性脑梗死的临床疗效及对脑血流动力学的影响[J].中国老年学杂志,2023,43(2):276-279.
[5] 赵建国, 高长玉, 顼宝玉, 等. 脑梗死和脑出血中西医结合诊断标准(试行)[J].中国中西医结合杂志, 2006, 26(10):948-949.
[6] 侯东哲,张颖,巫嘉陵,等.中文版美国国立卫生院脑卒中量表的信度与效度研究[J].中华物理医学与康复杂志,2012,34(5):372-374.
[7] 王杰.丁苯酞序贯治疗对急性脑梗死并认知障碍的作用及对患者NIHSS、mRS、ADL的影响[J].吉林医学,2022,43(5):1313-1315.
[8] 梁菊萍,杨旸,董继存. 急性脑梗死患者流行病学调查及危险因素[J].中国老年学杂志,2021,41(12):2484-2487.
[9] 何雪婷,马进. 缺血性中风的中医证治探析[J].中国民间疗法,2023,31(6):1-4.
[10] 王允明,王爱菊,陈海燕. 依达拉奉对急性脑梗死的治疗效果[J].实用医学杂志,2006,22(23):2760.
[11] FENG X J, LI Y, WANG Y N, et al. Danhong injection in cardiovascular and cerebrovascular diseases:pharmacological actions, molecular mechanisms, and therapeutic potential[J].Pharmacol Res,2019,139:62-75.
[12] 李一才,韩国胜,窦寿坦,等. 依达拉奉右莰醇联合丁苯酞注射液治疗急性进展性脑梗死患者的临床研究[J].中国临床药理学杂志,2023,39(6):763-767.
[13] 张园园,谭忠兵,管义祥. 血清UCH-L1水平与急性脑梗死的诊断及预后关系探讨[J].中国实验诊断学,2022,26(6):864-868.
[14] FENG C, WAN H F, ZHANG Y Y, et al. Neuroprotective effect of danhong injection on cerebral ischemia-reperfusion injury in rats by activation of the PI3K-Akt pathway[J].Front Pharmacol,2020,11:298.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(1): 135-137.