五阶梯营养支持对胃癌术后辅助化疗患者营养状态及化疗毒副反应的影响

doi:10.3969/j.issn.1671-7171.2024.10.031

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Abstract 【Objective】 To investigate the impact of five-step nutritional support on the nutritional status and side effects in patients undergoing postoperative adjuvant chemotherapy for gastric cancer. 【Methods】 Eighty patients undergoing postoperative adjuvant chemotherapy for gastric cancer were randomly divided into two groups, with 40 patients in each group. The observation group received five-step nutritional support, while the control group received conventional nutritional support. The nutritional status, blood biochemical indicators, chemotherapy side effects, and quality of life were compared between the two groups before and after the intervention. 【Results】After the intervention, the overall nutritional status subjective scoring (PG-SGA) decreased, while body mass index (BMI) and maximum calf circumference increased in both groups (P<0.05). The PG-SGA score in the observation group was lower than that in the control group, while both BMI and maximum calf circumference were higher in the observation group compared to the control group (P<0.05). After the intervention, hemoglobin (Hb), serum albumin (Alb), and serum prealbumin (PA) levels increased in both groups compared to before the intervention (P<0.05), and levels of Hb, Alb and PA in the observation group were higher than those in the control group (P<0.05). The overall incidence of chemotherapy side effects in the observation group (17.50%) was lower than that in the control group (45.00%) (P<0.05). At 3 and 6 months after the intervention, the scores of the Quality of Life Questionnaire for Gastric Cancer Patients in both groups were lower than those before the intervention, and the observation group's scores were lower than those of the control group (P<0.05). 【Conclusion】 The application of five-step nutritional support in patients undergoing postoperative adjuvant chemotherapy for gastric cancer can improve nutritional status, enhance blood biochemical indicators, reduce side effects, and improve the quality of life, making it worthy of clinical promotion and application.

Key words： Stomach Neoplasms/SU Antineoplastic Combined Chemotherapy Protocols Nutritional Support Drug-Related Side Effects and Adverse Reactions

Received: 10 May 2024

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R735.2

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	Articles by authors
	CHE Shuai
	LU Lunjie
	JIANG Xiao
	et al

Cite this article:

CHE Shuai,LU Lunjie,JIANG Xiao, et al. Effect of Five-Step Nutritional Support on the Nutritional Status and Chemotherapy Side Effects in Patients Undergoing Postoperative Adjuvant Chemotherapy for Gastric Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(10): 1564-1567.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.10.031 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I10/1564

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