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| Relationship between of Golgi Protein 73 and Myeloperoxidase 3 with the Prognosis of Chronic Hepatitis B-related Hepatocellular Carcinoma Related to Chronic Hepatitis B |
| SONG Zhifeng |
| Department of Oncology, The First People's Hospital of Luoyang,Luoyang Henan 471000 |
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Abstract 【Objective】 To explore the relationship between of Golgi protein 73 (GP73) and myeloperoxidase 3 (MPO3) with the prognosis of hepatocellular carcinoma (HCC) related to chronic hepatitis B (CHB).【Methods】 The study involved included 104 patients with CHB-related HCC as the observation group and 90 healthy volunteers as the control group. Serum levels of GP73 and MPO3 were compared between the two groups. A two-year follow-up was conducted to track the survival of the observation group. Based on survival outcomes, patients of the observation group were divided into the death group (21 cases) and the survival group (80 cases). Clinical data between the death and survival groups were compared, and risk factors affecting patient prognosis were analyzed. The predictive efficiency of GP73, MPO3, and their combined detection for patient prognosis was evaluated.【Results】 The GP73 level in the observation group was higher than that in the control group, while the MPO3 level was lower (P<0.05). The mortality rate of CHB-related HCC patients was 20.79% (21/101). The death group had higher proportions of patients in stage Ⅲ~Ⅳ, poorly differentiated tumors, maximum tumor diameter >5 cm, multiple tumors (>2), lymph node metastasis compared to the survival group, and elevated the level of GP73 was higher levels, with and lower MPO3 levels was lower in the death group than those in the survival group (P<0.05). Logistic regression analysis showed that clinical stage, GP73, and MPO3 were factors influencing patient prognosis (P<0.05). Receiver operating characteristic (ROC) curve analysis revealed that the area under the curve (AUC) for predicting patient prognosis using GP73, MPO3 alone, and their combined detection was 0.803, 0.717, and 0.913, respectively.【Conclusion】 Serum GP73 and MPO3 levels are correlated with the prognosis of CHB-related HCC patients. The combined detection of these two markers shows a higher predictive efficiency for patient prognosis.
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Received: 20 October 2023
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2024, Vol. 41 
