Abstract 【Objective】 To investigate the clinical diagnostic value of ultrasonography combined with carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in breast cancer. 【Methods】 A total of 90 patients with breast cancer (breast cancer group, n=90) and 87 patients with benign breast nodules (benign breast nodules group, n=87) admitted to our hospital from April 2019 to April 2023 were selected, and 100 healthy female volunteers (control group) were selected in the same period. All subjects were examined by ultrasound and serum CEA and AFP levels. The clinical diagnostic value of ultrasound combined with CEA and AFP in breast cancer was analyzed by receiver operating characteristic (ROC) curve. 【Results】 Vmax, RI and PI in breast cancer group were significantly higher than those in the benign breast nodules group and the control group (P<0.05). Serum CEA and AFP levels in the breast cancer group were significantly higher than those in the benign breast nodules group and the control group (P<0.05). Ultrasound combined with CEA and AFP had the highest diagnostic value for breast cancer (AUC=0.930), and the predictive sensitivity was 93.0% and 97.5%, respectively, which were higher than any single detection index (P<0.05). 【Conclusion】 Ultrasonography combined with CEA and AFP has high clinical value in the diagnosis of breast cancer. Compared with single detection, its combined application can significantly improve the diagnostic sensitivity and specificity of breast cancer.
TIAN Xiuli,LI Jinsong. The Value of Ultrasonography Combined with Serum CEA and AFP Levels in the Differential Diagnosis of Breast Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 85-87.
2024, Vol. 41 
