Abstract 【Objective】To explore the therapeutic effect of Enbipu capsules on transient ischemic attack (TIA) patients and its impact on related factors.【Methods】A total of 110 TIA patients were randomly divided into two groups,with 55 cases in each group. All patients received conventional treatment for TIA. The observation group was orally administered Enbipu capsules,while the control group was given enteric-coated aspirin tablets. Both groups were treated continuously for 14 days. The clinical efficacy,changes in inflammatory factors [serum hypersensitive C-reactive protein (hs-CRP),homocysteine (Hcy),interleukin-6 (IL-6),and matrix metalloproteinase-9 (MMP-9)],hemorheology indicators [whole blood viscosity at low shear rate (LS),whole blood viscosity at high shear rate (HS),and plasma viscosity (PV)],coagulation function indicators [fibrinogen (FIB),prothrombin time (PT),activated partial thromboplastin time (APTT)],and neurological function indicators [neurofunctional factor S-100B protein (S-100B) and neuron-specific enolase (NSE)] were compared between the two groups.【Results】The overall effective rate in the observation group was 92.73% (51/55),which was significantly higher than the 78.18% (43/55) in the control group with statistically significant difference (P<0.05). There were no significant differences of all indicators in both groups before treatment (P>0.05). Post-treatment levels of Hcy,hs-CRP,IL-6,and MMP-9 in both groups were significantly reduced compared to pre-treatment (P<0.05). And the post-treatment levels of Hcy,hs-CRP,IL-6,and MMP-9 in the observation group were significantly lower than those in the control group after treatment(P<0.05). Compared to before treatment,levels of LS,HS,and PV decreased significantly after treatment in both groups (P<0.05),while LS,HS and PV levels in the observation group were significantly lower than those in the control group (P<0.05). After treatment,FIB in both groups decreased significantly,while PT and APTT increased significantly (P<0.05); And FIB in the observation group after treatment was significantly lower than that in the control group after treatment,while both PT and APTT of the observation group after treatment were higher than those of the control group after treatment (P<0.05). S-100B and NSE levels after treatment in both groups decreased significantly if compared to pre-treatment (P<0.05); And levels of S-100B and NSE in the observation group were much lower than those in the control group (P<0.05).【Conclusion】Enbipu capsules have a significant therapeutic effect on TIA,which can effectively suppress inflammatory responses and significantly improve patients' hemorheology,coagulation function,and neurological function.
HUANG Liang,JIA Jun,QU Xinghan. Therapeutic Effect of Enbipu Capsules on Transient Ischemic Attack Patients and its Impact on Related Factors[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1385-1388.
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2023, Vol. 40 
