<sup>18</sup>F-FDG PET-CT显像代谢参数及血清ALB、PA水平与食管癌患者术后预后的相关性

doi:10.3969/j.issn.1671-7171.2023.09.008

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1202 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To explore the correlation of postoperative prognosis in patients with esophageal cancer with fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)-CT metabolic parameters and levels of serum albumin (ALB) and prealbumin (PA).【Methods】Ninety patients with esophageal cancer were divided into two groups according to prognosis: 30 patients with good prognosis and 60 patients with poor prognosis. General information,¹⁸F-FDG PET-CT metabolic parameters,serum nutritional indicators (ALB and PA) of both groups were collected and compared. Receiver operating characteristic curve (ROC) analysis was used to evaluate the value of ¹⁸F-FDG PET-CT metabolic parameters,ALB,and PA in predicting postoperative prognosis in patients with esophageal cancer,and multiple logistic regression analysis was used to identify the risk factors for poor postoperative prognosis.【Results】There were no significant differences in age,sex,smoking history,drinking history,height,weight,and family history between the two groups (P>0.05). The maximum standard uptake value (SUV_max),metabolic volume (MTV),and total lesion glycolysis (TLG) in the poor prognosis group were higher than those in the good prognosis group (P<0.05). The levels of ALB and PA in the poor prognosis group were lower than those in the good prognosis group (P<0.05). ROC analysis showed that SUV_max,MTV,TLG,ALB,PA could be used to predict poor postoperative prognosis in patients with esophageal cancer,with the areas under the curve being 0.985,0.913,0.963,0.726 and 0.731 respectively (all P<0.05). Multivariate logistic regression analysis confirmed that SUV_max ≥ 21.25,MTV ≥ 14.42 cm³,TLG ≥ 5.85,ALB < 52.795 g/L,and PA < 230.09 mg/L were risk factors for poor postoperative prognosis in patients with esophageal cancer (P<0.05).【Conclusion】The ¹⁸F-FDG PET-CT metabolic parameters and serum levels of ALB and PA can be used for predicting the prognosis of surgical patients with esophageal cancer. Clinicians can regularly monitor these indicators and promptly carry out postoperative follow-up chemotherapy to improve the prognosis.

Key words： Positron Emission Tomography Computed Tomography Esophageal Neoplasms/SU Serum Albumin Prealbumin/BL Prognosis

Received: 10 February 2023

PACS:

R735.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.09.008 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I9/1307

[1] 廖明,徐恩五,何哲. miR-216a、p63联合NPS评分对微创食管癌切除术后患者预后的评估价值[J].临床和实验医学杂志,2022,21(22):2411-2415.
[2] 宋春洋,祝淑钗,沈文斌,等. Ⅱ~Ⅲ期食管癌根治性切除术后患者预后的影响因素分析[J].天津医药,2020,48(3):209-215.
[3] 于宏彬,王磊,贾琎蕊,等.120例食管癌根治术患者术后中远期生存率及预后危险因素调查分析[J].实用医院临床杂志,2022,19(4):184-186.
[4] 贾东辉,杜宇,黄飞,等. 食管癌患者行根治性切除术后血清miR-216a和Bcl-2mRNA表达水平及与预后的相关性研究[J].现代检验医学杂志,2022,37(2):93-99.
[5] 中国医师协会放射肿瘤治疗医师分会,中华医学会放射肿瘤治疗学分会,中国抗癌协会肿瘤放射治疗专业委员会,等.中国食管癌放射治疗指南(2021年版)[J].国际肿瘤学杂志,2022,49(1):12-25.
[6] 刘凯,刘燕,黄莉,等. PD-1/PD-L1、TIM-3表达与食管癌临床病理特征及预后的关系[J].重庆医学,2022,51(1):65-69.
[7] 段东奎,卢万里,张耕瑞,等.FDG PET-CT显像代谢参数对食管癌近期疗效的预测价值分析[J].中国CT和MRI杂志,2021,19(10):79-81.
[8] 王涛,王振光. ¹⁸F-FDG PET/CT代谢参数在非小细胞肺癌预后评估中的应用及进展[J].中国肺癌杂志,2019,22(3):167-172.
[9] 郭孟刚,周海宁,杨绪全. 预后营养指数评估食管癌病人术后并发症及预后的临床价值[J].安徽医药,2021,25(5):898-902.
[10] OKADOME K,BABA Y,YAGI T,et al. Prognostic nutritional index,tumor-infiltrating lymphocytes,and prognosis in patients with esophageal cancer[J].Ann Surg,2020,271(4):693-700.
[11] 闫可,魏菀怡,杜星语,等.预后营养指数对老年食管癌患者根治性放疗后长期生存的预测价值[J].天津医药,2021,49(8):861-865.
[12] HAYASHI M,ABE M,FUJITA T,et al. Assessing the prognostic value of extranodal extension in esophageal cancer from the pathological staging perspective[J].J Invest Surg,2022,35(3):698-706.