厄贝沙坦氢氯噻嗪联合金匮肾气丸治疗高血压慢性心力衰竭患者的临床效果及对NLRP3/NF-κB通路的影响

doi:10.3969/j.issn.1671-7171.2023.08.030

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1192 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the clinical efficacy of irbesartan hydrochlorothiazide combined with the Jingui Shenqi Pill in the treatment of hypertensive chronic heart failure (CHF) and its impact on the nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3)/nuclear factor B (NF-κB) pathway. 【Methods】A total of 106 hypertensive CHF patients admitted to our hospital from May 2019 to May 2022 were randomly divided into an observation group (treated with irbesartan hydrochlorothiazide combined with the Jingui Shenqi Pill) and a control group (treated with irbesartan hydrochlorothiazide) using a random number table method,with 53 patients in each group. We compared the efficacy,traditional Chinese medicine syndrome scores,blood pressure levels,cardiac function [B-type brain natriuretic peptide (BNP),left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD)],NLRP3/NF-κB pathway [NLRP3,NF-κB,interleukin-1 (IL-1β),interleukin-18 (IL-18),tumor necrosis factor-α(TNF-α)],and safety between two groups. 【Results】The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05); After treatment,the observation group had lower scores of traditional Chinese medicine syndromes such as chest tightness,palpitations,difficulty lying flat,lower limb edema,palpitations,dizziness,tinnitus,lack of qi and lazy speech,fatigue and fatigue compared to the control group (P<0.05); After treatment,the systolic and diastolic blood pressure in the observation group were lower than those in the control group (P<0.05); After treatment,BNP,LVEDD,and LVESD in the observation group were lower than those in the Western medicine group,while LVEF was higher than that in the control group (P<0.05); After treatment,the NLRP3,NF-κB,IL-1β,IL-18,and TNF-α levels in the observation group were lower than those in the control group (P<0.05); There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). 【Conclusions】The combination of Irbesartan Hydrochlorothiazide and the Jinkui Shenqi Pill in the treatment of hypertensive CHF can effectively improve clinical symptoms and signs,lower blood pressure levels,improve cardiac function,inhibit NLRP3/NF-κB pathway activation,and is safe and reliable.

Key words： Hypertension/CO Heart Failure/CO Hydrochlorothiazide/PD Irbesartan/PD NLR Family,Pyrin Domain-Containing 3 Protein/DE

Received: 01 February 2023

PACS:

R541.3

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Wen-jing

Cite this article:

WANG Wen-jing. Effect of Irbesartan Hydrochlorothiazide Combined with Jinkui Shenqi Pill on Hypertensive CHF and its Influence on NLRP3/NF-κB Pathway[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1225-1228.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.08.030 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I8/1225

[1] DI PALO K E,BARONE N J. Hypertension and heart failure: prevention,targets,and treatment[J].Heart Fail Clin,2020,16(1):99-106.
[2] KIUCHI S,HISATAKE S,KABUKI T,et al.Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension[J].Clin Exp Hypertens,2020,42(6):539-544.
[3] 杜立文,张海英,张威威,等.复方中药联合西医防治慢性心力衰竭136例临床分析[J].四川中医,2019,37(5):78-80.
[4] 翟昌明,鲁放,张双,等.三草降压汤对自发性高血压大鼠心脏NF-κB/NLRP3/IL-1β信号通路的影响[J].环球中医药,2019,12(8):1143-1148.
[5] 中国老年学和老年医学学会心脑血管病专业委员会,中国医师协会心血管内科医师分会.老年高血压的诊断与治疗中国专家共识(2017版)[J].中华内科杂志,2017,56(11):885-893.
[6] 中国中西医结合学会心血管疾病专业委员会,中国医师协会中西医结合医师分会心血管病学专家委员会.慢性心力衰竭中西医结合诊疗专家共识[J].中西医结合心脑血管病杂志,2016,36(2):133-141.
[7] 冠心病中医临床研究联盟,中国中西医结合学会心血管疾病专业委员会,中华中医药学会心病分会,等.慢性心力衰竭中医诊疗专家共识[J].中医杂志,2014,55(14):1258-1260.
[8] KURBANOGˇLU S,YARMAN A.Simultaneous determination of hydrochlorothiazide and irbesartan from pharmaceutical dosage forms with RP-HPLC[J].Turk J Pharm Sci,2020,17(5):523-527.
[9] 余晗俏,俞章平,李超,等.厄贝沙坦氢氯噻嗪早期联合美托洛尔治疗老年心力衰竭患者的疗效及安全性[J].中华老年医学杂志,2019,38(8):844-847.
[10] 李安祥,谢冉.解读金匮肾气丸及其成药的演变与应用[J].中医药通报,2020,19(2):18-20.
[11] 贝红霞,姜聪娇,甘辉.金匮肾气丸对肾性高血压伴蛋白尿患者血清白蛋白及血脂水平的影响[J].中国中西医结合肾病杂志,2020,21(10):878-880.
[12] XIN J Z,WU J M,HU G M,et al.α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation[J].Acta Pharmacol Sin,2020,41(3):311-318.
[13] LUO M,YAN D S,SUN Q S,et al.Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF-kB/NLRP3 pathway[J].J Cell Biochem,2020,121(4):2994-3004.