高血压急症与亚急症患者血清同型半胱氨酸水平与心脑血管动脉粥样硬化的相关性

doi:10.3969/j.issn.1671-7171.2023.03.014

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Abstract 【Objective】 To investigate the correlation between serum homocysteine (Hcy) level and cardio cerebral atherosclerosis in hypertensive emergency and sub emergency patients. 【Methods】 Seventy-nine patients with hypertension emergency and sub emergency were selected were enrolled in the study The serum Hcy level was detected to evaluate the occurrence of cardio cerebral atherosclerosis. The patients with cardio cerebral atherosclerosis were the observation group (n=48),and the patients without cardio cerebral atherosclerosis were the control group (n=31). The general data and serum Hcy level of the two groups were compared,and the influencing factors of cardio cerebral atherosclerosis were analyzed by logistic regression; ROC was used to evaluate the predictive value of serum Hcy level in cardio cerebral atherosclerosis. 【Results】 There were no significant differences in terms of sex,age,BMI,smoking history,diabetes,hyperlipidemia,FPG,HbAlc,LDL-C,HDL-C between the two groups (P>0.05). The proportion of previous PCI history,cerebral infarction history,Cr,BUN,Gensini score and Hcy level in the observation group were higher than those in the control group (P<0.05). Logistic regression analysis showed that previous PCI history,cerebral infarction history,BUN,Gensini score and Hcy were the influencing factors of cardio cerebral atherosclerosis in hypertensive emergency and sub emergency patients (P<0.05). ROC analysis showed that the cut-off value of serum Hcy level in hypertensive emergency and sub emergency patients for the diagnosis of cardio cerebral atherosclerosis was 8.76 μmol/L and the AUC value was 0.974,with the sensitivity of 89.58% and specificity of 96.77%. 【Conclusion】 There is a close correlation between serum Hcy level and cardio cerebral atherosclerosis in hypertensive emergency and sub emergency patients,which can provide useful reference for clinical diagnosis and treatment.

Key words： Hypertension Emergencies Cysteine/BL Atherosclerosis

Received: 25 October 2022

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R544.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.03.014 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I3/370

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