|
|
|
| Association between IL-10 Gene Polymorphism and Susceptibility to Sepsis in Term Newborns |
| ZHAO Xiao-fen, YANG Mi-feng, ZHAO Peng-na, et al |
| Department of Neonatology,Kunming Children's Hospital,Yunnan Kunming 650228 |
|
|
|
|
Abstract 【Objective】 To investigate the correlation between the polymorphisms of IL-10 the susceptibility to sepsis in term newborns.【Methods】 A prospective analysis of the clinical data of 107 Han nationality term newborns admitted to our hospital from June 2020 to May 2021 was conducted. They were divided into sepsis group (56 newborns with sepsis) and control group (51 newborns with pharyngeal syndrome and non infectious diarrhea) based on whether they were diagnosed as sepsis. The polymorphism of the IL-10 rs1800872,rs1800896 gene was detected using first-generation sequencing technology,and the distribution differences of genotype and allele frequencies between the two groups were compared. Logistic regression was used to analyze the correlation between the IL-10 rs1800872C/A,1800896G/A genotypes and the susceptibility to sepsis in term infants. 【Results】 In the sepsis group,15 cases were positive for blood culture,including 9 cases of Escherichia coli,2 cases of Staphylococcus,1 case of Staphylococcus hemolyticus,1 case of Streptococcus viridis,1 case of Streptococcus lactis,and 1 case of Enterococcus faecium. The blood culture in the control group was negative. The WBC,serum CRP,and PCT levels in the sepsis group were significantly higher than those in the control group (P<0.05). There was no significant difference in the distribution of genotype and allele frequencies of IL-10 gene rs1800872C/A,rs1800896G/A between the two groups (P>0.05). Logistic regression analysis showed that there was no correlation between the genotype of IL-10 gene rs1800872C/A and rs1800896G/A and the susceptibility to sepsis in term newborns (P>0.05). 【Conclusion】 The IL-10 genes rs1800872C/A and rs1800896G/A may not be susceptible genes for sepsis in term newborns.
|
|
Received: 21 July 2022
|
|
|
|
|
|
[1] SRINIVASAN L,SWARR D T,SHARMA M,et al. Systematic review and meta-analysis:gene association studies in neonatal sepsis[J].Am J Perinatol,2017,34(7):684-692.
[2] BIZZARRO M J,JIANG Y,HUSSAIN N,et al. The impact of environmental and genetic factors on neonatal late-onset sepsis[J].J Pediatr,2011,158(2):234-238.
[3] STANILOVA S A. Functional relevance of IL-10 promoter polymorphisms for sepsis development[J].Crit Care,2010,14(1):119.
[4] FATANI S H,ALKHATIB K H,BADR H. Association of TNF-alpha-308 (G >A) (rs1800629) gene polymorphism with adverse outcomes of sepsis in critically Ⅲ patients[J].DNA Cell Biol,2020,39(9):1723-1729.
[5] GEORGESCU A M,BANESCU C,AZAMFIREI R,et al. Evaluation of TNF-alpha genetic polymorphisms as predictors for sepsis susceptibility and progression[J].BMC Infect Dis,2020,20(1):221.
[6] 中华医学会儿科学分会新生儿学组,中国医师协会新生儿科医师分会感染专业委员会.新生儿败血症诊断及治疗专家共识(2019年版)[J].中华儿科杂志,2019,57(4):252-257.
[7] VIVAS M C,VILLAMARIN-GUERRERO H F,SANCHEZ C A. Interleukin-10 (IL-10) 1082 promoter polymorphisms and plasma IL-10 levels in patients with bacterial sepsis[J].Rom J Intern Med,2021,59(1):50-57.
[8] PAN W,ZHANG A Q,YUE C L,et al. Association between interleukin-10 polymorphisms and sepsis:a meta-analysis[J].Epidemiol Infect,2015,143(2):366-375.
[9] RAGHUNATHAN V M,WHITESELL P L,LIM S H. Sleep-disordered breathing in patients with sickle cell disease[J].Ann Hematol,2018,97(5):755-762.
[10] 张媚溪.UC患者IL-10基因rs1800871、rs1800872、rs1800896位点基因多态性分析[J].齐齐哈尔医学院学报,2020,41(12):1456-1459.
[11] 马东红,刘云,石岩,等.IL-10基因多态性与中国北方人群糖尿病肾病易感性的关系[J].重庆医学,2018,47(26):3390-3393.
[12] MAO Z R,ZHANG S L,FENG B. Association of IL-10 (-819T/C,-592A/C and -1082A/G) and IL-6 -174G/C gene polymorphism and the risk of pneumonia-induced sepsis[J].Biomarkers,2017,22(2):106-112.
[13] AZAB S F,ABDALHADY M A,ELSAADANY H F,et al. Interleukin-10 -1082 G/A gene polymorphisms in Egyptian children with CAP:A case-control study[J].Medicine (Baltimore),2016,95(26):e4013. |
|
|
|
2023, Vol. 40 
