功能性消化不良患者心理状态与肠道菌群失调、胃肠动力的相关性

doi:10.3969/j.issn.1671-7171.2023.12.027

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Abstract 【Objective】 To explore the correlation between the psychological state of patients with functional dyspepsia (FD) and the imbalance of gut microbiota and gastrointestinal motility. 【Methods】Eighty FD patients admitted to our hospital from May 2020 to April 2021 were selected as the study subjects. Depression levels, Lactobacillius, Enterococcus, and 6-hour postprandial gastric emptying rate were evaluated using the Self Rating Depression Scale (SDS), quantitative and qualitative detection of fresh fecal specimens, and small barium X-ray gastric emptying test, respectively. Pearson correlation analysis was used to examine the relationship between psychological status, gut microbiota imbalance, and gastrointestinal motility in FD patients. 【Results】The SDS score of FD patients was (59.41±4.85) points, the Lactobacillus count was (6.45±1.27) lgCFU/g, the Enterococcus count was (7.41±1.04) lgCFU/g, and the gastric emptying rate at 6 hours after meals was (88.36±6.74)%. Pearson correlation analysis showed that SDS score was positively correlated with Enterococcus count (r=0.594, P<0.05), negatively correlated with postprandial gastric emptying rate at 6 hours (r=-0.721, P<0.05), and negatively correlated with Lactobacillus count (r=-0.622, P<0.05); Lactobacillus count was positively correlated with postprandial gastric emptying rate at 6 hours (r=0.580, P<0.05), and negatively correlated with Enterococcus (r=-0.491, P<0.05). The count of Enterococcus was negatively correlated with the gastric emptying rate at 6 hours after meals (r=-0.784, P<0.05). 【Conclusion】 Patients with functional digestion have a negative psychological state of depression, and clinical physicians should develop positive and reasonable psychological treatment methods to correct the patient's negative psychology, which can help improve the patient's gastrointestinal function and promote early recovery.

Key words： Dyspepsia Intestines/MI Gastrointestinal Motility

Received: 26 December 2022

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R573

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	YANG Ting
	LIU Wenqing
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Cite this article:

YANG Ting,LIU Wenqing,LIU Jinzhi, et al. A Study on the Correlation between Psychological State and Dysbiosis of Gut Microbiota and Gastrointestinal Motility in Patients with Functional Dyspepsia[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1916-1918.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.12.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I12/1916

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