Abstract 【Objective】To investigate the application value of echocardiographic parameters, including the foramen ovale valve length (FOV-L) and the ratio of foramen ovale diameter (FO-d) to atrial septal length (AS-L), in the diagnosis of patent foramen ovale in neonates. 【Methods】A retrospective analysis was conducted on clinical data from 90 pregnant women and their neonates who delivered in our hospital from June 2021 to June 2022. Based on the closure status of the foramen ovale three months after birth, neonates were divided into non-closure (n=54) and closure (n=36) groups. Prenatal echocardiographic measurements [fetal FOV-L, FO-d, AS-L, peak systolic velocity of the foramen ovale (FO-V)] were compared, and the ratios FOV-L/FO-d and FO-d/AS-L were calculated. Follow-up was conducted three months postpartum to observe the closure status of the neonatal foramen ovale. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of FOV-L and FO-d/AS-L for patent foramen ovale in neonates. Multifactorial logistic regression was used to analyze the risk factors for patent foramen ovale in neonates. The combined predictive value of FOV-L and FO-d/AS-L for patent foramen ovale in neonates was analyzed for consistency. 【Results】There was no statistically significant difference between the two groups in terms of FO-d, AS-L, FO-V, and FOV-L/FO-d (P>0.05). The non-closure group had significantly higher FOV-L and FO-d/AS-L than the closure group (P<0.05). ROC curve analysis showed that the areas under the curve for FOV-L and FO-d/AS-L in predicting patent foramen ovale in neonates were 0.847 and 0.827, respectively, with sensitivities of 0.759 for both and specificities of 0.833 and 0.778, respectively. Multifactorial logistic regression results indicated that FOV-L≥7.670 mm and FO-d/AS-L≥0.345 were risk factors for patent foramen ovale in neonates (P<0.05). Consistency analysis revealed that the combined prediction of FOV-L and FO-d/AS-L for patent foramen ovale in neonates had a sensitivity of 0.963, a specificity of 0.861, an accuracy of 0.922, and a Kappa value of 0.836. 【Conclusion】 Echocardiographic parameters are somewhat correlated with patent foramen ovale in neonates. Both FOV-L and FO-d/AS-L can be used to predict patent foramen ovale in neonates, with a higher predictive value when combined.
WEI Yuxiu,LIU Mengmei,YANG Duo. Application Value of Echocardiographic Parameters in the Diagnosis of Patent Foramen Ovale in Neonates[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(10): 1475-1477,1481.
2023, Vol. 40 
