Effects of Thalidomide Combined with Precise Radiotherapy and Chemotherapy on Serum miR-451 and miR-21 Levels and Prognosis in Patients with Esophageal Cancer
WANG Li-yan, LIU Xiao-xia
Department of Tumor center,Shandong Provincial Third Hospital,Jinan Shandong 250031
Abstract【Objective】 To investigate the effect of thalidomide combined with precise radiotherapy and concurrent chemotherapy on serum microrRNA-451 (miR-451) and microrRNA-21 (miR-21) levels and prognosis in patients with esophageal cancer.【Methods】 A total of 96 patients with esophageal cancer were randomly divided into two groups,with 48 cases in each group.The control group was given precise radiotherapy combined with concurrent chemotherapy,while the observation group was given thalidomide combined with precise radiotherapy and chemotherapy.After 2 months of treatment,the short-term efficacy,incidence of adverse reactions,serum levels of carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125),macrophage inflammatory protein-3α(MIP-3α),miR-451,miR-21 and follow-up results were compared between the two groups before and after treatment.【Results】 The disease remission rate of the observation group was 70.83%,which was significantly higher than that of the control group (50.00%,P<0.05).The incidence of radiation esophagitis and hematotoxicity in the observation group was significantly lower than that in the control group (P<0.05).There was no significant difference in the incidence of radiation bronchitis,esophageal stenosis and pulmonary fibrosis between the two groups (P>0.05).After treatment,the serum levels of CEA,CA125,MIP-3α,miR-451 and miR-21 in the two groups were significantly lower than those before treatment (P<0.05),and the observation group was significantly lower than the control group (P<0.05).The 3-year cumulative survival rate of the observation group was 58.70%,which was significantly higher than that of the control group (33.33%) (P<0.05).【Conclusion】 Compared with precise radiotherapy and concurrent chemotherapy,thalidomide combined with precise radiotherapy and concurrent chemotherapy has more accurate short-term and long-term efficacy in the treatment of esophageal cancer.It can lower the level of tumor markers and serum miR-451,miR-21 levels,and reduce the risk of radiation esophagitis and blood toxicity.
WANG Li-yan,LIU Xiao-xia. Effects of Thalidomide Combined with Precise Radiotherapy and Chemotherapy on Serum miR-451 and miR-21 Levels and Prognosis in Patients with Esophageal Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(1): 53-56.
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2023, Vol. 40 
