|
|
|
| Study on the Relationship between the Expression of Mismatch Repair Protein and Ki67 Protein and Progression Free Survival after Colorectal Cancer Resection in the Elderly |
| DANG Li-li, LI Jin |
| Department of General Surgery,Hanzhong Central Hospital,Hanzhong Shaanxi 723000 |
|
|
|
|
Abstract 【Objective】 To investigate the relationship between the expression of mismatch repair protein and Ki67 protein and progression free survival (PFS) after resection of colorectal cancer (CRC) in the elderly. 【Methods】 From October 2016 to October 2021, 96 elderly patients with CRC who underwent radical resection of colorectal cancer in Hanzhong Central Hospital were selected, and colorectal cancer tissue specimens and adjacent tissues were collected. The expression of mismatch repair protein and Ki67 protein in cancer tissues and adjacent tissues were compared.The expression of mismatch repair protein and Ki67 protein in colorectal cancer tissues and adjacent tissues were compared. The correlation between the expression of mismatch repair protein and Ki67 protein in cancer tissues and their clinicopathological characteristics was analyzed. Cox regression analysis was used to analyze the related factors affecting the prognosis of elderly CRC patients, and to analyze the correlation between the expression of mismatch repair protein and Ki67 protein and PFS in elderly CRC patients after radical surgery. 【Results】 The negative expression rate of mismatch repair protein and the positive expression rate of Ki67 protein in colorectal cancer tissues were higher than those in adjacent tissues (P<0.05). The negative expression rate of mismatch repair protein and the positive expression rate of Ki67 protein in the cancer tissues of elderly CRC patients with different tumor diameter, clinical stage, lymph node metastasis, degree of differentiation and depth of invasion were statistically significant (all P<0.05). Ninety six elderly patients with CRC were followed up for 3 years, 3 patients were lost, and 21 of the remaining 93 patients (22.58%) died. Cox regression analysis showed that tumor diameter, clinical stage, lymph node metastasis, degree of differentiation, negative expression of mismatch repair protein and positive expression of Ki67 protein were independent factors affecting the prognosis of elderly CRC patients (P<0.05). The survival curve of patients with positive expression of mismatch repair protein was significantly different from that of patients with negative expression (P<0.05). The survival curve of patients with negative Ki67 protein expression was significantly different from that of patients with positive Ki67 protein expression (P<0.05). 【Conclusion】 The expression rate of mismatch repair protein (MRP) is negative and Ki67 protein is positive in elderly CRC patients. The expressions of MRP and Ki67 protein are correlated with the clinicopathological characteristics and prognosis of the patients.
|
|
Received: 10 January 2022
|
|
|
|
|
|
[1] OSUMI H,SHINOZAKI E,YAMAGUCHI K,et al.Clinical utility of circulating tumor DNA for colorectal cancer[J].Cancer Sci,2019,110(4):1148-1155.
[2] 陈小勇,邓丽亚,宣世海,等.血清巨噬细胞抑制因子-1癌胚抗原及糖类抗原联合检测在老年结直肠癌诊断和预后中的应用[J].中华老年医学杂志,2019,38(11):1289-1293.
[3] MCGRAIL D J,GARNETT J,YIN J,et al.Proteome instability is a therapeutic vulnerability in mismatch repair-deficient cancer[J].Cancer Cell,2020,37(3):371-386.
[4] 陈攀丽,唐建荣,张逸强.黄芪甲苷对人结肠癌SW480细胞系增殖和凋亡的影响[J].肿瘤防治研究,2019,46(8):702-706.
[5] 国家卫生计生委医政医管局,中华医学会肿瘤学分会.中国结直肠癌诊疗规范(2015版)[J].中华胃肠外科杂志,2015,16(10):961-973.
[6] 刘成玉,罗春丽.临床检验基础[M].第5版.北京:人民卫生出版社,2012:32-33.
[7] 牟晓峰.现代临床检验学[M].上海:科学技术文献出版社,2012:46-47.
[8] DARIYA B,ALIYA S,MERCHANT N,et al.Colorectal cancer biology,diagnosis,and therapeutic approaches[J].Crit Rev Oncog,2020,25(2):71-94.
[9] 李恒,庄肃非,杨春,等.结直肠癌错配修复蛋白表达及与预后的相关性分析[J].宁夏医科大学学报,2020,42(7):688-691.
[10] MENON S S,GURUVAYOORAPPAN C,SAKTHIVEL K M,et al.Ki-67 protein as a tumour proliferation marker[J].Clin Chim Acta,2019,491(18):39-45.
[11] 冯强.微卫星不稳定性及错配修复蛋白与结直肠癌疗效相关性及预后的研究[D].苏州:苏州大学,2019.
[12] TONG G,ZHANG G,LIU J,et al.Cutoff of 25% for Ki67 expression is a good classification tool for prognosis in colorectal cancer in the AJCC8 stratification[J].Oncol Rep,2020,43(4):1187-1198. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(1): 139-141. |
|
|
|
|
2023, Vol. 40 
