Abstract 【Objective】 To investigate the predictive efficacy of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the prognosis of glioma. 【Methods】A total of 114 patients with gliomas admitted to The First People's Hospital of Xianyang from February 2017 to February 2020 were examined by DCE-MRI. The quantitative parameters of plasma extracellular space volume transfer constant (Ktrans) and extravascular extracellular space fraction (Ve) were recorded, and the prognosis was evaluated according to the progression free survival (PFS) after adjuvant chemotherapy after glioma resection. The general data of different prognosis, Ktrans and Ve were compared, the influencing factors of glioma prognosis were analyzed by logistic regression, and the predictive value of Ktrans and Ve on prognosis was evaluated by receiver operating characteristic curve (ROC curve). 【Results】Among 114 patients with glioma, 71 had poor prognosis and 43 had good prognosis; The age and high-grade proportion of patients with poor prognosis were greater than those with good prognosis, and KPS score, postoperative radiotherapy proportion and temozolomide use ≥ 4 courses were lower than those with good prognosis (P<0.05); DCE-MRI quantitative parameters Ktrans and Ve in patients with poor prognosis were greater than those in patients with good prognosis (P<0.05). Multivariate logistic regression analysis showed that age, tumor grade, Ktrans, Ve were risk factors for prognosis, KPS score, postoperative radiotherapy, temozolomide use ≥4 courses were protective factors for prognosis (P<0.05). ROC curve analysis showed that the cut off value of DCE-MRI quantitative parameters Ktrans and Ve to predict prognosis was 0.172/min and 0.205, and the AUC value was 0.932 and 0.890. 【Conclusion】 DCE-MRI quantitative parameters Ktrans and Ve are important factors affecting the poor prognosis of patients with glioma, and have important clinical predictive value for prognosis evaluation.
YANG Yi,SHI Yong. Predictive Efficacy of Dynamic Contrast-enhanced MRI Quantitative Parameters on the Prognosis of Glioma[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 1068-1071.
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2022, Vol. 39 
