Effect of Hyperbaric Oxygen Combined with Cefazolin Sodium on Neurological Function and Reticulocyte Related Parameter in Children with Infectious Jaundice
Abstract 【Objective】 To explore the effect of hyperbaric oxygen combined with cefazolin sodium on neurological function and reticulocyte related parameter in children with infectious jaundice. 【Methods】A total of 118 children with infectious jaundice in Xinxiang Central Hospital from February 2019 to April 2021 were selected and divided into the observation group and the control group by random number table, with 59 cases in each group. On the basis of conventional treatment, the control group was treated with cefazolin sodium alone, while the observation group was treated with hyperbaric oxygen combined with cefazolin sodium. Patients in both groups received treatment for 7 days. Clinical efficacy, jaundice subsidence time, time for serum total bilirubin(TBIL) to return to normal level, hospitalization time and serum neurological function-related indexes before treatment and 7 days after treatment [Astrocyte-derived protein (S100B), β-amyloid protein (Aβ) , Neuron specific enolase (NSE)], TBIL,reticulocyte related parameters [low nucleic acid reticulocyte ratio (L-RTC%), high fluorescent reticulocyte ratio (H-TC%) , Reticulocyte percentage (RET%)] level, and the occurrence of adverse reactions were compared between the two groups. 【Results】After treatment, the total effective rate in the observation group was 91.53% (54/59), which was higher than 72.88% (43/59) in the control group. The difference was statistically significant (χ2=7.010,P=0.008). The jaundice subsidence time, serum TBIL recovery time, and the hospitalization time in the observation group were shorter than those in the control group (P<0.05). After 7 days of treatment, The serum levels of S100B, Aβ, NSE, and TBIL in the two groups were lower than those before treatment; and the observation group was lower than that of the control group (P<0.05). The levels of L-RTC% and RET% in the two groups were lower than those before treatment, and the levels of H-TC% were higher than those before treatment, and the difference between the two groups was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The use of hyperbaric oxygen combined with cefazolin sodium in the treatment of children with infectious jaundice can improve the neurological function of the children, adjust the levels of TBIL, WBC, NLR, and reticulocyte related parameters, and promote the recovery of the children. It is safe and effective.
GAO Shi-kai,CHEN Jian,REN Jing-jing. Effect of Hyperbaric Oxygen Combined with Cefazolin Sodium on Neurological Function and Reticulocyte Related Parameter in Children with Infectious Jaundice[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 1040-1043.
2022, Vol. 39 
