龙胆泻肝汤联合多柔吡星注射剂治疗带状疱疹后遗神经痛的疗效观察

doi:10.3969/j.issn.1671-7171.2022.05.026

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Abstract 【Objective】 To observe the efficacy of Longdan Xiegan decoction combined with doxorubicin injection in the treatment of postherpetic neuralgia (PHN). 【Methods】 A total of 80 PHN patients admitted to Longxian Maternal and Child Health Hospital from December 2017 to December 2020 were collected in the study. They were randomly divided into two groups, with 40 cases in each group. Patients in the control group w received intraforaminal injection of doxorubicin under CT guidance, while patients in the observation group received Longdan Xiegan Decoction + doxorubicin for 1 month. The clinical efficacy, TCM syndrome score and visual analog scale (VAS) score were compared between the two groups. Blood was collected before and after treatment to detect serum inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), Interleukin-2 (IL-2)] and the expression of immune cells [CD4⁺, CD8⁺, CD4⁺/CD8⁺], and the incidence of adverse reactions between the two groups were compared. 【Results】 The total effective rate of the observation group was 90.00%, which was significantly higher than that of the control group (72.50%, P<0.05). Compared with before treatment, TCM syndrome score and VAS score of the two groups decreased significantly after treatment; And the observation group was significantly lower than the control group (P<0.05). After treatment, the contents of TNF-α and IL-1β in the two groups decreased (P<0.05), while the contents of IL-2 increased (P<0.05). Compared with the control group, TNF-α and IL-1β in the observation group decreased more, while IL-2 increased more; The differences were statistical significance (P<0.05). After treatment, CD4⁺ and CD4⁺/CD8⁺ increased (P<0.05) and CD8⁺ decreased (P<0.05) in the two groups, and the changes in the observation group were more obvious than those in the control group (P<0.05). The incidence of adverse reactions in observation group was 20.00%, which was not statistically significant compared with 17.50% in control group (P>0.05). 【Conclusion】 Longdan Xiegan Decoction combined with doxorubicin injection has obvious curative effect on PHN, which can promote pain relief, reduce inflammatory reaction and enhance immune function. It is safe for clinical application.

Key words： Herpes Zoster/CO Neuralgia, Postherpetic/DT LONGDAN XIEGAN DECOCTION/TU Doxorubicin/TU

Received: 17 December 2021

PACS:

R745.11

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	CAO Yun-chao
	MA Jian

Cite this article:

CAO Yun-chao,MA Jian. Efficacy of Longdan Xiegan Decoction Combined with Doxorubicin Injection in Treatment of Postherpetic Neuralgia[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 736-739.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.05.026 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I5/736

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