急性心肌梗死患者血清lncRNA MALAT1水平与心肌损伤标志物、凝血功能指标的相关性研究

doi:10.3969/j.issn.1671-7171.2022.04.021

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Abstract 【Objective】To detect the expression level of long non-coding RNA-lung adenocarcinoma metastasis-associated transcription factor 1 (IncRNA MALAT1) in serum of patients with acute myocardial infarction and analyze its relationships with marks of myocardial injury and coagulation function in actual myocardial infarction (AMI). 【Methods】A total of 103 patients with acute myocardial infarction admitted to our hospital from January 2017 to January 2019 were selected as the observation group, and 103 healthy volunteers who were examined in our hospital during the same period were selected as the control group. The level of lncRNA MALAT1 in serum was detected by qRT-PCR and the levels of myocardial injury markers and coagulation factors were detected by ELISA. The correlations of the level of lncRNA MALAT1 with myocardial injury and coagulation function were analyzed. 【Results】The levels of NT-proBNP, CK-MB, CK, cTnI, MYO, coagulation indexes such as PT, APTT, INR, FIB, vWF, PAI-1 and serum lncRNA MALAT1 in acute myocardial infarction group were significantly higher than those in healthy control group (all P<0.05), while the values of PT, APTT and INR were lower than those in the control group, and the differences were statistically significant. (P<0.05). Serum lncRNA MALAT1 was positively correlated with NT-proBNP, CK-MB, cTnI, vWF and PAI-1 in patients with acute myocardial infarction (P<0.05), and IncRNA MALAT1 level was negatively correlated with PT and APTT (P<0.05). High NT-proBNP level, high CK-MB level, low APTT level, high vWF level and high lncRNA MALAT1 level were risk factors for acute myocardial infarction (all P<0.05). 【Conclusion】The expression level of serum lncRNA MALAT1 of patients with acute myocardial infarction was significantly increased, which may promote the occurrence of acute myocardial infarction by influencing the changes of myocardial markers and coagulation indexes.

Key words： Myocardial Infarction Acute Disease RNA, Long Noncoding Myocardium/PA Blood Coagulation

Received: 07 December 2021

PACS:

R542.22

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	WANG Xing
	HU Ya-hong

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WANG Xing,HU Ya-hong. Study on Correlation of Serum lncRNA MALAT1 Level with Markers of Myocardial Injury and Coagulation Function in Patients with Acute Myocardial Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 553-556.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.04.021 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I4/553

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