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| Effect of Simvastatin Combined with Conventional Therapy on Renal Function and Renal Fibrosis in Patients with Early Diabetic Nephropathy |
| YIN Jun, QIU Jun-si, SHAO Fang |
| Department of Nephrology, Wuxi Second People's Hospital, Wuxi Jiangsu 214000,China |
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Abstract 【Objective】To explore the effect of simvastatin combined with conventional treatment on renal function and renal tissue fibrosis in patients with early diabetic nephropathy. 【Methods】A total of 88 patients with early diabetic nephropathy who were admitted to our hospital were selected and randomly divided into the observation group (simvastatin combined with conventional treatment) and the control group (conventional blood glucose control), with 44 cases in each group. The control group received conventional blood glucose control, while the observation group received simvastatin in addition to the conventional blood glucose control group. The clinical effective rate, renal function indexes [serum creatinine (SCr), urea nitrogen (BUN), β2 - microglobulin (β2 - MG), urinary albumin-to-creatinine ratio (UACR), and 24 - hour urinary protein quantitation], renal fibrosis indexes [type IV collagen (Ⅳ-C), transforming growth factor (TGF-β1), and tissue matrix metalloproteinase inhibitor-1 (TIMP-1)] were compared between the two groups after treatment, and the adverse drug reactions during treatment were observed as well. 【Results】After treatment, the total effective rate in the observation group was 86.36% (38/44), which was higher than 65.91% (29/44) in the control group, and the difference was statistically significant (P<0.05).After treatment, the levels of SCr, BUN, β2-MG, UACR and 24h urinary protein in both groups decreased (P<0.05), and the observation group showed even lower level (P<0.05). After treatment, the levels of Ⅳ-C, TGF-β1 and TIMP-1 in the two groups decreased (P<0.05), and the comparison between the two groups showed that the level in the observation group were lower than the control group (P<0.05). The adverse reactions of the observation group was 18.18% (8/44) and of the control group was 25.00% (11/44), which showed no difference (P>0.05).【Conclusion】Simvastatin combined with conventional treatment can improve the clinical efficiency and renal function, while slow down the process of renal fibrosis in patients with early diabetic nephropathy, with high safety.
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Received: 22 December 2021
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2022, Vol. 39 
