Abstract 【Objective】To explore the risk factors of intracranial infection after neurosurgical class Ⅰ incision craniotomy. 【Methods】 The clinical data of 725 patients who underwent class Ⅰ incision craniotomy in our hospital from January 2018 to December 2019 were analyzed retrospectively. The possible risk factors were analyzed by univariate analysis and multivariate logistic regression analysis. 【Results】Intracranial infection occurred in 63 of 725 patients (8.69%). Univariate analysis showed that age >50 years, BMI >27 kg/m2, operation time >4 h, diabetes history, emergency operation, open lateral ventricle, preoperative prophylactic use of antibiotics, drainage tube, postoperative cerebrospinal fluid leakage, and intraoperative microscopy were associated risk factors for intracranial infection after operation (P<0.05). Multivariate Logistic regression analysis showed that age, history of diabetes, preoperative antibiotic use, cerebrospinal fluid leakage, and drainage tube were independent risk factors for intracranial infection after operation (P<0.05). 【Conclusion】Age, history of diabetes, preventive use of antibiotics, indwelling drainage tube and cerebrospinal fluid leakage are risk factors for intracranial infection after craniotomy. Clinical preventive measures should be taken to intervene early in these risk factors, so as to reduce the incidence of intracranial infection after operation.
ZHANG Shi-yuan,SHI Hai-ping,ZENG Chun, et al. Analysis of Related Risk Factors of Intracranial Infection after Class Ⅰ Incision Craniotomy[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 481-483.
[1] JIANG L,GUO L,LI R,et al.Targeted surveillance and infection-related risk factors of nosocomial infection in patients after neurosurgical operation[J].Pak J Pharm Sci,2017,30(3):1053-1056. [2] 崔向丽,林松,隋大立,等. 神经外科术后颅内感染的诊疗进展[J].中华神经外科杂志,2014,30(3):312-314. [3] 中华医学会神经外科学分会. 中国神经外科重症患者感染诊治专家共识(2017)[J].中华医学杂志,2017,97(21):1607-1614. [4] SHI Z H, XU M, WANG Y Z,et al. Post-craniotomy intracranial infection in patients with brain tumors:a retrospective analysis of 5723 consecutive patients[J].Br J Neurosurg,2017,31(1):5-9. [5] 邱政,郑绍俭,张晓东,等. 开颅手术患者术后颅内感染病原学特点及危险因素分析[J].中华医院感染学杂志,2017,27(20):4693-4696. [6] McClelland S. Postoperative intracranial neurosurgery infection rates in North America versus Europe:a systematic analysis[J].Am J Infect Control,2008,36(8):570-573. [7] 刘荣华,段奎甲. 颅脑术后颅内感染相关危险因素分析[J].中国临床神经外科杂志,2017,22(6):407-409. [8] 沈罡,朱光耀,孙成丰,等. 脑胶质瘤手术患者术后颅内感染病原学特点及危险因素分析[J].中华医院感染学杂志,2017,27(20):4697-4715. [9] 王向鹏,尚亚军,邓兴力,等. 听神经鞘瘤术后颅内感染的危险因素分析[J].中华医院感染学杂志,2015,25(1):176-180. [10] LIEBER B A, APPELBOOM G, TAYLOR B E,et al. Preoperative chemotherapy and corticosteroids:independent predictors of cranial surgicalsite infections[J].J Neurosurg,2016,125(1):187-195. [11] 刑永国,孟伟英,张淑祥,等. 神经外科开颅术后颅内感染诊治新进展[J].中华医院感染学杂志,2016,26(22):5268-5271. [12] GIDAY S A, DRAY X, MAGNO P, et al. Infection during natural orifice transluminal endoscopic surgery:a randomiazed, controlled study in a live porcine model[J].Gastrointest Endosc,2010, 71(4):812-816. [13] 李元叶,冯燕,孙春燕. 颅内肿瘤切除术后颅内感染病原菌特点及危险因素分析[J].中国肿瘤外科杂志,2019,11(6) :420-423.
2022, Vol. 39 
