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| Study on Relationship of Severity of Illness in Patients Bitten by Agkistrodon with Serum NLR and PLR Levels |
| ZENG Xian-hua, QIN Shuang-quan, LUO Li-hui |
| Department of Emergency Nard, Changde First People's Hospital, Changde Hunan, 415003, China |
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Abstract 【Objective】To investigate the relationship the severity of agkistrodon bite with neutrophil-to-lymphocyte ratio (NLR)and platelet-lymphocyte ratio (PLR) levels in patient serum.【Methods】There are 143 cases of patients bitten by agkistrodon in total who were admitted to our Hospital. Of which, 115 patients were selected based on the inclusion and exclusion criteria. According to the Snake Bite Severity Scale (SSS) score, they were divided into 45 cases in the mild group,(0~3 points), 40 cases in the moderate group (4~7 points), and 30 cases in the severe group (8~20 points). During the same time period, 20 healthy volunteers were randomly selected from Health Management Center and divided into the healthy control group. The levels of NLR, PLR, high-sensitivity C-reactive protein(hs-CRP), procalcitonin (PCT), interleukin-1 (IL-1) and interleukin-6 (IL-6) in each group were compared. After that, the relationship of severity of the disease in patients bitten by agkistrodon with levels of NLR and PLR was analyzed.【Results】Serum NLR and PLR were positively correlated with the severity of snake bite (P<0.05). Compared with the control group, the levels of NLR and PLR in the snake poisoning groups were significantly increased (P<0.05). Compared to patients in the mild and moderate groups, the levels of NLR and PLR in the severe group were significantly higher (P<0.05). Compared with the patients in the mild group, the levels of NLR and PLR in the moderate group were Increased (P>0.05). Compared to the control group, the levels of hs-CRP, PCT, IL-1, and IL-6 were significantly higher in the agkistrodon poisoning groups (all P<0.05). Among the poisoning groups, levels of hs-CRP, PCT, IL-1, and IL-6 in the mild group were lower than those in the moderate group and the severe group, however, the difference between the mild group and the moderate group was not statistically significant (All P>0.05) and the difference between the mild group and the severe group was statistically significant (P<0.05).【Conclusion】Both NLR and PLR are positively correlated with the severity of patients bitten by agkistrodon.
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Received: 23 August 2021
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2022, Vol. 39 
