孕期体重增加值、血清25羟基维生素D水平与糖脂代谢指标的相关性分析

doi:10.3969/j.issn.1671-7171.2022.12.025

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1151 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To explore the relationship of nutritional indexesand serum vitamin D[25-(OH) D] level with glucose/ lipid metabolism during pregnancy. 【Methods】A total of 120 pregnant women in the second trimester of pregnancy who were admitted to our hospital from March 2020 to July 2021 were selected as the research objects. The weight gain (GWG) of all pregnant women during pregnancy was measured. The levels of serum 25-(OH)D,fasting blood glucose (FPG),two-hour postprandial blood glucose (2hPG),glycosylated hemoglobin (HbAlc),triglycerides (TG),total cholesterol (TC),low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) were measured. The differences of glucose and lipid metabolism indexes among pregnant women with different levels of GWG and 25-(OH)D were analyzed. 【Results】According to the serum 25-(OH)D level during pregnancy,36 cases (30.00%) were in the normal group,49 cases (40.83%) in the deficiency group,24 cases (20%) in the deficiency group and 11 cases (9.17%) in the severe deficiency group. The levels of serum TG,TC,LDL-C,HbAlc,FPG and 2hPG in the normal,deficient,deficient,and severely deficient groups of serum 25-(OH)D levels increased sequentially; and the differences between groups were statistically significant (P< 0.05).The levels of serum HDL-C in four groups were normal group > insufficient group > deficient group > severe deficiency group (P<0.05). Pearson correlation analysis showed that 25-(OH)D level were negatively correlated with TG,TC,LDL-C,HbAlc,FPG and 2hPG, while HDL-C was positively correlated with 25-(OH)D levels (P<0.05). According to GWG,there were 31 cases (25.83%) in the excess group,62 cases (51.67%) in the appropriate group and 27 cases (22.50%) in the excess group. The levels of TG,TC,and LDL-C in the lack of group,the appropriate group,and the excessive group increased sequentially; and the difference between the groups was statistically significant (P<0.05). While the HDL-C level decreased sequentially,and the difference between the groups was statistically significant (P<0.05).The levels of HbAlc,FPG and 2hPG in the lack of group and the excessive group were higher than those in the appropriate group (P<0.05),but there were no significant differences in the levels of HbAlc,FPG and 2hPG between the two groups (P>0.05). Pearson correlation analysis showed that too little GWG was negatively correlated with TG,TC,LDL-C,HbAlc,FPG and 2hPG,and it was positively correlated with HDL-C (P<0.05). Also,the too much GWG was positively correlated with HDL-C,HbAlc,FPG and 2hPG,while it was negatively correlated with TG,TC and LDL-C (P<0.05). 【Conclusion】Lack of 25-(OH)D level and too much or too little GWG during pregnancy are closely related to glucose and lipid metabolism. Detecting 25-(OH)D and GWG in time during pregnancy and adjusting them within an appropriate range are the effective means to avoid the disorder of glucose and lipid metabolism.

Key words： Pregnant Women Weight Gain Calcifediol/BL Glycolipids/ME

Received: 18 May 2022

PACS:

R714.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YANG Xian-ting
	CAO Yi-ran

Cite this article:

YANG Xian-ting,CAO Yi-ran. Study on the Relationship of Weight Gain and Serum Vitamin D Level with Glucose/ Lipid Metabolism during Pregnancy[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(12): 1848-1851.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.12.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I12/1848

[1] FURSE S,FERNANDEZ-TWINN D S,CHIARUGI D,et al. Lipid metabolism is dysregulated before,during and after pregnancy in a mouse model of gestational diabetes[J].Int J Mol Sci,2021,22(14):7452-7453.
[2] ZHOU Y,PENG H,XU H,et al. Maternal diet intervention before pregnancy primes offspring lipid metabolism in liver[J].Lab Invest,2020,100(4):553-569.
[3] CHEN H Y,ZHANG H P,YANG J,et al. The relationship between maternal vitamin D deficiency and glycolipid metabolism and adverse pregnancy outcome[J].Clin Endocrinol (Oxf),2020,93(6):713-720.
[4] 曾芳玲,张丽娜,章向红,等. 妊娠期妇女体重增加的研究[J].中国妇幼保健,2003,18(6):353-355.
[5] ENKHMAA D,TANZ L,GANMAA D,et al. Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women[J].Ebio Med,2019,39(1):510-519.
[6] LOKKI A I,HEIKKINEN-ELORANTA J,ÖHMAN H,et al. Smoking during pregnancy reduces vitamin D levels in a Finnish birth register cohort[J].Public Health Nutr,2020, 23(7):1273-1277.
[7] 王楠,全莉梅,章根琴,等. 妊娠期糖尿病患者血清25羟维生素D₃及血脂水平分析[J].中华全科医学,2021,19(7):1147-1149.
[8] 王孝君,谭先凤,段昆茂,等. 孕妇血清25-羟维生素D₃水平与妊娠期糖尿病的相关性[J].中国妇幼保健,2020,35(13):2372-2375.
[9] 程锦,严宇,朱守斌,等. 妊娠期糖尿病患者外周血25-羟基维生素D、脂蛋白相关磷脂酶A2表达及相关性[J].中国计划生育学杂志,2021,29(5):955-959.
[10] 肖黄梦,陈妍,裴玲,等. 妊娠期糖尿病患者孕期血脂水平对产后糖脂代谢的影响[J].中山大学学报(医学科学版),2020,41(3):479-484.
[11] 唐明燕,朱秋平. 孕期体质量管理对妊娠期糖尿病患者糖脂代谢及妊娠结局的影响[J].医学临床研究,2020,37(9):1410-1412.
[12] 王润秋,桑琳,杜世华. 妊娠期糖尿病患者不同孕期脂代谢及巨大儿发生[J].中国计划生育学杂志,2020,28(2):251-256.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(1): 133-135.