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| Effects of General Anesthesia with Tracheal Intubation Alone or Combined with Peripheral Nerve Block on Acute and Chronic Pain and Plasma Anti-x Factor Activity in Patients with Knee Joint Replacement |
| XIE Ya-ning, GUO Xiao-wei, CEHN Hai-ni, et al |
| Xi'an People's Hospital Xi'an Fourth Hospital,Anesthesia and Perioperative Medicine Center Xi'an, Shaanxi, 710000 |
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Abstract 【Objective】To explore the effects of two different anesthesias (simple tracheal intubation general anesthesia and general anesthesia combined with peripheral nerve block) on postoperative acute and chronic pain and plasma clotting factor X activity in patients undergoing knee arthroplasty. 【Methods】A total of 150 patients undergoing knee arthroplasty in our hospital were randomly divided into two group, with 75 cases in each group. The control group only used tracheal intubation general anesthesia, while the observation group used tracheal intubation general anesthesia combined with peripheral nerve block anesthesia. The anesthesia onset time, recovery time, and hemodynamic index levels of the two groups, postoperative pain and changes in the activity of anticoagulant factor X activity in the body after surgery were compared between the two groups. 【Results】Intraoperative recovery time of the observation group was significantly lower than that of the control group (P<0.05). The systolic blood pressure, diastolic blood pressure, and heart rate levels of the control group were significantly lower than those before the operation (P<0.05), while the hemodynamics of the observation group did not show difference before and after surgery; the difference was not statistically significant (P>0.05). The visual analog pain (VAS) score of the observation group was significantly lower than that of the control group at 6 hours after the operation (P<0.05). The observation group was The activities of anticoagulant factor X activity at 10 minutes, 20 minutes, and 60 minutes after the operation was higher than those of the control group (P<0.05).【Conclusion】General anesthesia combined with peripheral nerve block anesthesia for tracheal intubation can significantly reduce the postoperative pain response of patients, with stable hemodynamics and higher activity of anticoagulant factor Xa.Thus the anesthesia effect is superior.
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Received: 10 March 2020
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2022, Vol. 39 
