Abstract 【Objective】 To investigate the correlation between galectin-3 (Gal-3) and recurrence after radiofrequency ablation in patients with atrial fibrillation.【Methods】The clinical data of 90 patients with atrial fibrillation treated by radiofrequency ablation in the Department of Cardiology of our hospital from June 2016 to June 2018 were selected. They were divided into recurrence group (n=27) and non recurrence group (n=63) according to whether they relapsed after operation. The concentration of serum Gal-3 was detected by sandwich enzyme-linked immunosorbent fluorescence method, and the effect of serum Gal-3 level on the recurrence of atrial fibrillation after ablation was analyzed by Cox regression model.【Results】Among the 90 patients with atrial fibrillation, 48 patients (53.3%) had persistent atrial fibrillation, and 24.4% had CHA2DS2 -VASC score>2. Warfarin was the main anticoagulant (60.0%). There were significant differences in age, type of atrial fibrillation, CHA2DS2-VASC score, left atrial diameter (LAD), serum amino terminal B-type pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP) and Gal-3 between recurrent group and non recurrent group (P<0.05). Univariate Cox regression analysis showed that age, LAD, persistent atrial fibrillation and the levels of serum Gal-3 and hs-CRP were the risk factors for postoperative recurrence of atrial fibrillation (P<0.05). Multivariate Cox regression analysis showed that persistent atrial fibrillation, LAD and serum Gal-3 and hs-CRP levels were independent risk factors for recurrence after RFCA in patients with atrial fibrillation (P<0.05).【Conclusion】The level of serum Gal-3 is an independent risk factor for recurrence after RFCA in patients with atrial fibrillation.
ZHOU Na,CHEN Jun-min. Correlation between Serum Galectin 3 Level and Recurrence after Radiofrequency Ablation in Patients with Atrial Fibrillation[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(9): 1371-1374.
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