肺鳞状细胞癌组织热休克蛋白90的表达及其临床意义

doi:10.3969/j.issn.1671-7171.2021.07.002

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Abstract 【Objective】To investigate the expression of heat shock protein 90(HSP90) in lung squamous cell carcinoma and analyze the relationship between its expression and clinicopathological characteristics and prognosis. 【Methods】 The cancer tissues of 159 lung squamous cell carcinoma(SCC) patients with complete follow-up data and 53 non-cancer control lung tissues(Non-CLT), who were selected from the thoracic surgery of the Second Xiangya Hospital of Central South University between 2003 and 2013, were retrospectively evaluated. High-throughput tissue microarray(TMA) were constructed and the expression of HSP90 were detected by immunohistochemistry(IHC). Kaplan-Meier univariate and Cox multivariate hazard regression analysis were performed to assess the prognosis of patients with lung SCC. 【Results】 Compared with Non-CLT, the positive expression rate of HSP90 in lung SCC tissue was significantly higher(P<0.05); and the expression level of HSP90 in clinical stage Ⅲ patients was higher than that in clinical stage Ⅰ-Ⅱ patients(P=0.010). The expression level of HSP90 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P=0.016). The overall survival rate of patients with lung squamous cell carcinoma with high expression of HSP90 was significantly lower than that of patients with low expression of HSP90(P=0.002). Cox multivariate risk regression analysis found that patients with lung SCC with high expression of HSP90 had a worse prognosis than low expression of HSP90(P=0.042). 【Conclusion】 In addition to the clinical stage and pathological grade of the tumor, the high expression of HSP90 can be used as an independent molecular marker for evaluating the poor prognosis of patients with surgically removed lung SCC.

Key words： Lung Neoplasms/PA Carcinoma, Squamous Cell/PA HSP90 Heat-Shock Proteins/AN

Received: 17 May 2021

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R734.2

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.07.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I7/966

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