食管癌组织中ALC1、PLR-3表达与肿瘤临床病理特征的关系

doi:10.3969/j.issn.1671-7171.2021.06.027

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1239 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the relationship of ALC1 (amplification of liver cancer protein) and PLR-3 (protein tyrosine phosphatase-3) expression with the pathological features of esophageal cancer. 【Methods】Eighty cases of esophageal cancer tissue specimens obtained by surgical treatment in our hospital and 40 specimens of adjacent paracancerous tissues were selected. Western blotting analysis was used to detect the relative expression levels of ALC1 protein and PLR-3 protein in the two groups. The expression intensities of ALC1 protein and PLR-3 protein in esophageal carcinoma tissues with different TNM stage, lymph node metastasis, tumor differentiation degree and depth of invasion were analyzed. 【Results】The relative expression levels of ALC1 protein and PLR3 protein in esophageal carcinoma were significantly higher than those in adjacent tissues (P<0.05). The relative expression intensity of ALC1 protein in esophageal carcinoma tissues with different TNM staging and lymph node metastasis did show differently. The difference was statistically significant (P<0.05). The relative expression intensity of PLR3 protein in esophageal carcinoma tissues with lymph node metastasis was statistically significant difference from that in esophageal cancer tissues without lymph node metastasis (P<0.05). 【Conclusion】The expression of ALC1 and PLR-3 in esophageal cancer tissues was significantly up-regulated and closely related to the occurrence and development of tumors.

Key words： Esophageal Neoplasms /PA Neoplasms Cell Proliferation Protein Tyrosine Phosphatases

Received: 07 November 2019

PACS:

R735.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHAO Min
	SUN Feng-ling
	XUE Niu-yan

Cite this article:

ZHAO Min,SUN Feng-ling,XUE Niu-yan. Relationship of ALC1 and PLR-3 Expression with Pathological Features of Esophageal Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 900-902.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.06.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I6/900

[1] 李金蔓.食管癌术后并发症分级及其影响因素分析[J].中国胸心血管外科临床杂志, 2017,9(4):259-264.
[2] 李芳芳, 马磊, 张振,等.ALC1蛋白在食管鳞癌中的表达及其对细胞增殖侵袭迁移的影响[J].中国肿瘤临床, 2018,18(11):572-576.
[3] 董文伟, 冯丽, 刘珊珊,等.ALC1与EZH2在肝癌细胞内的定位表达及相关性分析[J].解剖学研究, 2014,19(4):269-273.
[4] 陈月, 邹大进, 张征,等.肿瘤坏死因子α和罗格列酮对3T3-L1细胞分化过程中蛋白酪氨酸磷酸酶1B表达的影响[J].中华内分泌代谢杂志, 2007, 23(3):275-278.
[5] 班振英, 曾宪旭, 焦艳,等.蛋白酪氨酸磷酸酶PRL-3在乳腺癌中表达及意义[J].中华实用诊断与治疗杂志, 2012, 26(4):349-351.
[6] DIEM S, SCHMID, SABINE, KRAPF, MIRJAM, et al.Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab[J].Lung Cancer,2017, 111(12):176.
[7] 季晓频.ALC1基因在结直肠癌中的生物学作用及其分子机制研究[D].上海交通大学, 2011.
[8] BRANCHINI B R, SOUTHWORTH, TARA L, FONTAINE, DANIELLE M, et al.Red-emitting chimeric firefly luciferase for,in vivo, imaging in low ATP cellular environments[J].Analyt Biochem,2017, 534(12):36-39.
[9] 黄伟华, 来伟, 篮球生,等.蛋白酪氨酸磷酸酶-3对结肠癌细胞表皮生长因子相关信号通路的调节[J].岭南现代临床外科, 2015, 15(3):348-350.
[10] LEHMANN L C, HEWITT, GRAEME, AIBARA, SHINTARO, et al.Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1[J].Molecular Cell,2017, 68(5):847-859.
[11] 许鹤洋, 刁飞宇, 曾育杰,等.蛋白酪氨酸磷酸酶-3通过诱导肿瘤性巨噬细胞钙离子依赖性钾离子通道表达增强LoVo细胞侵袭性[J].中华实验外科杂志, 2013, 30(8):1666-1667.
[12] TSUDA,MASATAKA, CHO,KOSAI, OOKA,MASATO, et al.ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair[J].PLoS One,2017, 12(11):188320.