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| Expression of Serum FGF-21 and Apelin in Pregnant Women with Hypothyroidism and Correlation with Blood Lipids and Low Birth Weight Neonates |
| YANG Ju-mei, LI Yong-li |
| Department of Obstetrics, Xi'an Aerospace General Hospital, Xi'an Shaanxi 710100 |
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Abstract 【Objective】 To investigate the expression of serum fibroblast growth factor 21 (FGF-21) and Apelin in pregnant patients with hypothyroidism and correlation with blood lipids and low-birthweight neonates. 【Methods】 From January 2018 to June 2019, 85 patients with hypothyroidism during pregnancy were selected as the observation group, and 90 normal pregnant women were selected as the control group. Thyroid hormone levels, blood lipid levels, serum FGF-21, Apelin expression levels were compared between the two groups, and the correlation of serum FGF-21 and Apelin expression levels with blood lipid and low birth weight was analyzed. 【Results】 The TSH level of the observation group was significantly higher than that of the control group (P<0.05), while the levels of FT3 (free triiodothyronine) and FT4 (free thyroxine) were significantly lower than those in the control group (P<0.05). The levels of FGF-12, Apelin, TG, TC and HDL in the observation group were significantly higher than those in the control group (P<0.05), and the level of LDL in the observation group was significantly lower than that in the control group (P<0.05). The incidence of low birth weight newborns in the observation group was 2.35% (2/85), which was lower than 10.00%(9/90) in the control group. The difference was statistically significant between the two groups (χ2=4.340,P=0.037). The results of correlation analysis showed that serum FGF-21 and Apelin levels in pregnant women with hypothyroidism were was positively correlated with TG, TC and the incidence of low neonatal weight (P<0.05), negatively correlated with LDL (P<0.05) and not significantly correlated with HDL (P> 0.05). 【Conclusion】 Serum Apelin and FGF-21 expression levels increased in patients with hypothyroidism during pregnancy, and the expression levels of Apelin and FGF-21 were positively correlated with lipid metabolism indicators such as TG and TC. It may participate in the occurrence and development of the disease by affecting the patient's metabolic level, and ultimately affect the perinatal outcome.
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Received: 01 February 2021
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[1] 周娟, 侯雯雯, 朱烨,等. 妊娠中期单纯性甲状腺自身抗体阳性及单纯性低甲状腺素血症对妊娠结局的影响[J].安徽医药, 2018, 22(11):2180-2183.
[2] 叶凤如, 黄玉玲, 彭海燕,等. 宫腔粘连分离术后宫腔留置节育器联合不同剂量雌激素对宫腔再粘连、月经恢复及妊娠率的影响[J].医学临床研究, 2018, 35(6):1086-1088.
[3] XI C,BAI J,JUN X,et al. Effects of thyroid peroxidase antibody on maternal and neonatal outcomes in pregnant women in an iodine-sufficient area in China[J].Int J Endocrinol,2016, 2016:6461380.
[4] 中华医学会内分泌学分会, 中华医学会围产医学分会. 妊娠和产后甲状腺疾病诊治指南[J].中华内分泌代谢杂志, 2012, 28(5):354-367.
[5] 刘赛, 张弛, 李华珠, 等. 2012年中华医学会《妊娠及产后甲状腺疾病诊治指南》和2011年ATA《妊娠及产后甲状腺疾病诊治指南》诊断妊娠中晚期亚临床甲减的分析[C]//中华医学会第十二次全国内分泌学学术会议.
[6] 吕飞娟, 王佑民. 亚临床甲状腺功能减退合并妊娠期糖尿病的临床研究[J].中国临床药理学杂志, 2018, 34(12):1213-1214.
[7] 徐少元, 张昌军, 胡玥玥,等. IVF-ET助孕后早期自然流产的相关因素分析[J].医学临床研究, 2018,35(3):573-575.
[8] 王小菊,龙燕,蔺莉.不同诊断标准下妊娠期亚临床甲状腺功能减退与不良妊娠结局的相关性研究[J].临床和实验医学杂志,2019,18(11):1194-1198.
[9] CHENG X,ZHU B,JIANG F,et al. Serum FGF-21 levels in type 2 diabetic patients[J].Endocr Res,2011, 36(4):142-148.
[10] SEMBA R D,SUN K,EGAN J M,et al. Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the baltimore longitudinal study of aging[J].J Cell Physiol,2012, 97(4):1375-1382.
[11] 张小露. 血清Apelin水平监测在糖尿病视网膜病变诊断中的意义[J].广东医学, 2016, 37(18):2779-2781.
[12] 马坤, 郑少林, 李红, 等. 糖调节受损痰湿证患者Apelin水平及相关因素分析[J].世界中西医结合杂志, 2015,10(8):1128-1131.
[13] 王大为, 付研. 2型糖尿病患者血浆apelin水平与血管并发症的相关性分析[J].中国医刊, 2014,63(11):23-27.
[14] 孙可歆, 李锋, 王子宇,等. 甲状腺功能减退患者血清FGF-21的表达水平及其生化指标相关性分析[J].中国地方病防治杂志, 2016,30(11):44-45. |
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2021, Vol. 38 
