C1q/肿瘤坏死因子相关蛋白6在2型糖尿病患者血清中的表达及其意义

doi:10.3969/j.issn.1671-7171.2021.04.024

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Abstract 【Objective】 To investigate the correlation of serum CTRP6 level with insulin resistance in patients with type 2 diabetes. 【Methods】 Ninety patients with type 2 diabetes newly diagnosed in our hospital from June 2017 to April 2019 were selected as the observation group, and 90 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group. General data such as age, gender, height, body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) of the two groups of candidates were collected.CTRP6, glycated hemoglobin (HbA1c), fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG), fasting insulin (FINS), triglycerides (TG), total cholesterol (TC), and low density lipoprotein ( LDL-C), high-density lipoprotein (HDL-C), interleukin 6 (IL-6), and insulin resistance indicator HOMA-RI.Compare the biochemical index levels of the two groups were mearsured. Taken the CTRP6 as the dependent variable and each index as the independent variable, multiple regression analysis was performed to further analyze the relationship between CTRP6 and each index. 【Results】 The CTRP6 and HDL-C in the observation group were significantly lower than those in the control group (P<0.05). The levels of HOMA-IR, HbA1c, FPG, 2hPG, FINS, TG, TC, LDL-C, and IL-6 in the observation group were significantly higher than those in the control group ( P<0.05).Correlation analysis showed that CTRP6 levels were not significantly related to age, gender, height, SBP, DBP, and TC (P>0.05); CTRP6 levels were negatively related to HOMA-IR, HbA1c, FPG, 2hPG, FINS, TG, LDL-C and IL -6 (P<0.05), and CTRP6 level was positively correlated with HDL-C (P<0.05).Multiple regression analysis was performed using CTRP6 level as the dependent variable and HOMA-IR, HbA1c, FPG, 2hPG, FINS, TG, and BMI as independent variables. The results showed that HOMA-IR, HbA1c, and TG were independent risk factors of CTRP6 (P<0.05). 【Conclusion】 CTRP6 level in patients with type 2 diabetes is significantly lower than normal adults. The level of CTRP6 in patients with type 2 diabetes is closely related to insulin resistance. HOMA-IR, TG, and HbA1c are independent influencing factors of CTRP6.

Key words： Diabetes Mellitus, Type 2 Complement System Proteins/BL

Received: 28 October 2020

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R587.1

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	ZHANG Wen-tao
	ZHANG Ni

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ZHANG Wen-tao,ZHANG Ni. Expression and Significance of CTRP6 (C1q/ TNF-Related Protein 6) in Serum of Patients with Type 2 Diabetes Mellitus[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(4): 562-565.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.04.024 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I4/562

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