外周静脉血肿瘤异常蛋白检测对乳腺癌患者的疗效监测及评估价值<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2021.04.008

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Abstract 【Objective】 To explore the efficacy monitoring and evaluation of tumor abnormal protein (TAP) in peripheral venous blood in patients with breast cancer. 【Methods】 A total of 80 cases of female breast cancer patients (the breast cancer group) admitted to the hospital and 68 healthy female volunteers (the control group) who underwent physical examination in our hospital at the same time period were selected for the study. The TAP levels between the breast cancer group and the control group were compared. According to the effect of chemotherapy, breast cancer patients were further divided into the effective group and the ineffective group. The clinical data of effective group and ineffective group were compared. Logistic regression analysis was used to analyze the influencing factors on the therapeutic efficacy of breast cancer patients. Receiver operating characteristic curve (ROC) was used to analyzed the evaluation value of tap in peripheral venous blood for the treatment effect of breast cancer patients. 【Results】 The TAP level of breast cancer group before treatment was higher than that of the control group (P<0.05). The total effective rate of chemotherapy for breast cancer patients was 48.75% (39/80). Compared to the effective group, patients in the ineffective group has higher proportion of clinical staging Ⅲ, poor differentiation, lymph node metastasis, estrogen receptor, progesterone receptor composition ratio and higher TAP level after treatment (P<0.05). The TAP decline rate in the ineffective group was lower than that in the effective group, the difference was statistically significant (P<0.05). Logistic regression analysis results showed that clinical stage, degree of differentiation, lymph node metastasis and TAP decline rate were the influencing factors in the treatment effect of breast cancer patients (P<0.05). ROC analysis showed that the optimal cut-off point for TAP to evaluate the treatment effect of breast cancer patients was 15.59%, with a sensitivity of 73.17%, a specificity of 82.05%, and an AUC value of 0.811. 【Conclusion】 TAP level in the peripheral venous blood is abnormally high in breast cancer patients, and the change of TAP levels before and after treatment is closely related to the treatment effect of breast cancer patients, so it can be used to monitor and evaluate the efficacy of breast cancer patients.

Key words： Breast Neoplasms/DI Breast Neoplasms/TH Neoplasm Proteins/AN

Received: 05 January 2021

PACS:

R737.9

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	SHEN Wei-juan
	ZHANG Yi

Cite this article:

SHEN Wei-juan,ZHANG Yi. Monitoring and Evaluating Value of Tumor Abnormal Protein Detection in Peripheral Venous Blood of Patients with Breast Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(4): 508-511.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.04.008 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I4/508

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