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| Effect of Tranexamic Acid in Different Time Windows on the Prognosis of Traumatic Brain Injury |
| NI Yan-qing, GU Yun-lai, FENG Jun-feng |
| Shanghai Pudong New Area Medical Emergency Center, Shanghai 201206, China |
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Abstract 【Objective】 To compare the effects of tranexamic acid on the prognosis of patients with traumatic craniocerebral trauma . 【Methods】 A prospective randomized controlled trial was conducted to analyze the clinical data of 126 patients with traumatic brain injury (GCS ≤ 12), which includes 72 males and 54 females . The patients were divided into Group A (time window < 30 minutes, 46 cases), Group B (time window =1 hour, 42 cases), and Group C (time window =3 hours, 38 cases). Patients of Group A received an intravenous injection of tranexamic acid with a dosage of 1 g at the scene of emergency aid (time window < 30 minutes); patients of Group B took an intravenous injection of tranexamic acid with a dosage of 1 g after admission (time window=1 hour), and patients of Group C took an intravenous injection of 1 g tranexamic acid after a complete examination (time window=3 hours). The operations and other medications were performed according to the routine operations. The average time of ambulance arrivals and the average time of transportation are recorded, and the plasma levels of FDP and D-dimer were observed at the time of admission and 1 day after injury, and a comparison of the times of ICU, DIC score and Glasgow Outcome Score (GOS) at 3 months after injury was also performed. 【Results】 There was no significant difference in the arrival times of ambulance among the three groups. The levels of FDP and D-dimer in the three groups were totally similar (P>0.05). However, 1 day after hospital admission, FDP and D-dimer in the Group A are significantly lower than those in the group B and C; DIC score and NICU time in the Group A were significantly lower than those in the other two groups. The GOS score and prognosis of the Group A were higher in 3 months after injury, and the differences were statistically significant (P<0.05). 【Conclusion】 Tranexamic acid can effectively improve the traumatic coagulation dysfunction, it is available to reduce progressive intracranial hemorrhage with a better prognosis.
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Received: 12 January 2021
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2021, Vol. 38 
