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| Application of Single and Combined Detection of FER, AFP and AFP-L3 in Diagnosis and Therapeutic Evaluation of Hepatocellular Carcinoma |
| SHAN Yong-feng, YU Hao, LIU Hui, et al |
| Fifth People's Hospital of Wuxi, Jiangsu Province 214001 |
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Abstract 【Objective】To explore the application value of ferritin (FER), alpha fetoprotein (AFP), alpha fetoprotein-L3 (AFP-L3) in the diagnosis and evaluation of curative effect of hepatocellular carcinoma (HCC). 【Methods】A total of 80 patients with HCC were selected as the HCC group. And 80 patients with benign liver disease were selected as benign liver disease group. The levels of FER,AFP,AFP-L3 were measured on the day of admission, and the diagnostic value of each index for HCC was analyzed. All patients with HCC received radiofrequency ablation. The therapeutic effect was analyzed one month after operation. The evaluation value of serum FER, AFP and AFP-L3 was analyzed. 【Results】The serum FER, AFP and AFP-L3 levels in HCC group were significantly higher than those in the benign liver disease group ( P <0.05).The sensitivity of FER, AFP and AFP-L3 alone in the diagnosis of HCC was 72.50%, 77.50% and 81.25% respectively. The specificity was 78.75%, 87.50% and 86.25%, respectively. The accuracy rates were 75.63%, 82.50% and 83.75%, respectively. The consistency of Kappa test with pathological diagnosis was 0.513, 0.650 and 0.675.The sensitivity, specificity, accuracy and consistency of FER, AFP and AFP-L3 in the diagnosis of hepatocellular carcinoma were 90.00%, 92.50%, 91.25% and 0.825.The sensitivity, specificity and accuracy of FER and AFP combined with AFP-L3 in the diagnosis of HCC were 90.00%, 92.50% and 91.25%, respectively. Its consistency with pathological diagnosis was 0.825. Among 80 cases of liver cancer patients, 65 cases were effective after treatment, and the overall response rate was 81.25%. The serum levels of FER, AFP and AFP-L3 in the effective treatment group were significantly lower than those in the ineffective treatment group ( P <0.05).The area under the curve of FER, AFP and AFP-L3 alone for evaluating the curative effect of HCC alone was 0.671, 0.688 and 0.716. The area under the curve of FER, AFP and AFP-L3 combined evaluation was 0.797. 【Conclusion】Serum level of FER, AFP and AFP-L3 alone has certain value in the diagnosis and evaluation of curative effect of HCC and the combined evaluation has the best effect.
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Received: 13 June 2019
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2021, Vol. 38 
