冷沉淀血浆输注治疗急性消化道大出血的止血效果及其对T细胞亚群水平的影响

doi:10.3969/j.issn.1671-7171.2021.03.021

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Abstract 【Objective】To investigate the hemostatic effect of cryoprecipitated plasma infusion in the treatment of acute gastrointestinal hemorrhage and its influence on the level of T cell subsets.【Methods】A total of 140 patients with acute gastrointestinal hemorrhage admitted to our hospital from December 2015 to December 2018 were divided into the observation group ( n =70) and the control group ( n =70) according to random number table method. Both groups were given routine symptomatic treatment.The control group was infused with fresh frozen plasma, while the observation group was given cryoprecipitated plasma infusion. The clinical hemostatic effect of the two groups was compared, and the red blood cell volume and hospital stay of the two groups were recorded. Blood samples were collected before and after treatment. T cell subsets including CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺, were measured by flow cytometry. The incidence of adverse reactions was recorded. 【Results】The total effective rate of the observation group (95.71%) was significantly higher than that of the control group (85.71%) ( P <0.05).The amount of erythrocyte transfusion in the observation group was significantly lower than that in the control group, and the time of hemostasis and hospitalization was significantly shorter than that in the control group ( P <0.05).After treatment, CD3⁺, CD4⁺, CD4⁺/CD8⁺ in both groups were significantly lower than those before treatment, and CD8⁺ was higher than that before treatment ( P <0.05).After treatment, CD3⁺, CD4⁺, CD4⁺/CD8⁺ in the observation group were still significantly higher than those in the control group, and CD8⁺ was significantly lower than those in the control group ( P <0.05).There was no significant difference in the incidence of non-hemolytic fever, allergy and hemosiderinosis between the two groups ( P >0.05). 【Conclusion】Cryoprecipitated plasma infusion can reduce the amount of red blood cells after transfusion, shorten the time of hemostasis and hospital stay, reduce post transfusion immunosuppression, without increasing the rate of adverse reactions, with high safety and significant overall efficacy.

Key words： Gastrointestinal Hemorrhage/TH Acute Disease Digestive System/BS Blood Component Transfusion/MT Hemostasis

Received: 29 August 2019

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R573.2

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	REN Jiao-xue
	DENG Lei

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REN Jiao-xue,DENG Lei. Hemostatic Effect of Cryoprecipitated Plasma Infusion on Acute Gastrointestinal Hemorrhage and Its Effect on T cell Subsets[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(3): 392-395.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.03.021 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I3/392

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