Abstract【Objective】 To study the efficacy and safety of radiofrequency ablation of (RFA) combined with dendritic cells-cytokines-induced killer cells (DC-CIK) in the treatment of advanced primary liver cancer. 【Methods】 A total of 86 patients with advanced primary liver cancer in our hospital from January 2018 to June 2019 were selected and randomly divided into control group (treated with RFA) and observation group (treated with RFA combined with DC-CIK immunotherapy), 43 cases in each group. The serum indexes, immune function, liver function and survival of patients were observed before and after treatment, and the short-term efficacy and incidence of adverse reactions were compared between the two groups.【Results】 The disease control rate of the observation group was 79.07% (34/43), which was significantly higher than 41.86% (18/43) of the control group (P<0.05). After treatment, the levels of serum alpha fetoprotein (AFP), carcinoembryonic antigen (CEA) and vascular endothelial growth factor (VEGF) in the observation group were significantly decreased (P<0.05), and were lower than those in the control group (P<0.05); while the levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in the observation group were higher than those before treatment, and were lower than those in the control group, the difference was statistically significant (P<0.05).The CD3+、CD4+、CD4+/CD8+ of peripheral blood T cell subsets in the observation group were significantly higher than those before treatment, and were significantly higher than those in the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 27.91% (12/43), which was higher than 23.26% (10/43) in the control group, and the difference was not statistically significant (P>0.05). The 1-year and 3-year survival rates of the observation group were significantly higher than those of the control group (all P<0.05).【Conclusion】 RFA combined with DC-CIK immunotherapy is effective in the treatment of patients with advanced primary liver cancer. It can reduce the level of serum tumor markers, improve the immune function, reduce the degree of liver function damage, prolong the survival rate, and has good safety, which is worthy of clinical application.
WU Wei. Clinical Efficacy and Safety of Radiofrequency Ablation Combined with DC-CIK Immunotherapy for Advanced Primary Liver Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(2): 269-271.
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